Evidence map›Paper›PMID 25654975›Full record

ReviewJournal of molecular endocrinology2015

The Krüppel-like factors in female reproductive system pathologies.

Rosalia C M Simmen, Melissa E Heard, Angela M Simmen, Maria Theresa M Montales, Meera Marji, Samantha Scanlon, John Mark P Pabona

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of molecular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

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  16. Effect of aging on the female reproductive function.Contraception and reproductive medicine · 2017
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rosalia C M SimmenDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA simmenrosalia@uams.edu.
Melissa E HeardDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
Angela M SimmenDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
Maria Theresa M MontalesDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
Meera MarjiDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
Samantha ScanlonDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
John Mark P PabonaDepartment of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USADepartment of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan 48109, USADepartment of Internal MedicineHarlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA.
University of Arkansas for Medical Sciences · USHarlem Hospital Center · USMichigan Medicine · US

Funding

UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENTR01HD021961 · NICHD · UNIVERSITY OF FLORIDA · PI SIMMEN, ROSALIA C · 1991 to 2008
$2.1M
Dietary Factors in Colon Cancer PreventionR01CA136493 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI SIMMEN, FRANK ALBERT · 2010 to 2014
$1.4M
UTEROFERRIN GENE EXPRESSION DURING DEVELOPMENTR29HD021961 · NICHD · UNIVERSITY OF FLORIDA · PI SIMMEN, ROSALIA C · 1986 to 1990
–
NCI NIH HHS CA136493NCI NIH HHS R01 CA136493NICHD NIH HHS HD21961NICHD NIH HHS R01 HD021961
6 · The paper itself

Abstract

Female reproductive tract pathologies arise largely from dysregulation of estrogen and progesterone receptor signaling, leading to aberrant cell proliferation, survival, and differentiation. The signaling pathways orchestrated by these nuclear receptors are complex, require the participation of many nuclear proteins serving as key binding partners or targets, and involve a range of paracrine and autocrine regulatory circuits. The members of the Krüppel-like factor (KLF) family of transcription factors are ubiquitously expressed in reproductive tissues and have been increasingly implicated as critical co-regulators and integrators of steroid hormone actions. Herein, we explore the involvement of KLF family members in uterine pathology, describe their currently known molecular mechanisms, and discuss their potential as targets for therapeutic intervention.

Indexed as

Amino Acid SequenceFemaleGene Expression RegulationGenitalia, FemaleHumansKruppel-Like Transcription FactorsMolecular Sequence DataOvarySignal TransductionUterusKruppel-Like Transcription Factorsendometrial pathologiesKLFNotchprogesteroneWnt

Identifiers

PMID25654975
PMCPMC4369192
OpenAlexW2137053400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.