ArticleRadiology2015
Multiparametric MR Imaging Depicts Glycosaminoglycan Change in the Achilles Tendon during Ciprofloxacin Administration in Healthy Men: Initial Observation.
Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Quantitative Sodium MRI of the Human Patellar Tendon.NMR in biomedicine · 2026Article
- Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon.Magnetic resonance in medicine · 2026Article
- Relationship Between Quantitative MRI UTE T2* of ACL Autografts and BMI-Normalized Knee Laxity Within the First Year After ACL Reconstruction.The American journal of sports medicine · 2025Article
- An indentation-based framework for probing the glycosaminoglycan-mediated interactions of collagen fibrils.Journal of the mechanical behavior of biomedical materials · 2023Article
- Evaluation of Sodium Relaxation Times and Concentrations in the Achilles Tendon Using MRI.International journal of molecular sciences · 2022Article
- Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging.Journal of magnetic resonance imaging : JMRI · 2021Review
- Differences in the magnetic resonance imaging parameter T2* may be identified during the course of canine patellar tendon healing: a pilot study.Quantitative imaging in medicine and surgery · 2021Article
- A fast multislice sequence for 3D MRI-CEST pH imaging.Magnetic resonance in medicine · 2021Article
- Article
- Repurposing Clinical Agents for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging: Current Status and Future Perspectives.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Uremic Toxins and Ciprofloxacin Affect Human Tenocytes In Vitro.International journal of molecular sciences · 2020Article
- Age-related decrease in collagen proton fraction in tibial tendons estimated by magnetization transfer modeling of ultrashort echo time magnetic resonance imaging (UTE-MRI).Scientific reports · 2019Article
- Sugar-based biopolymers as novel imaging agents for molecular magnetic resonance imaging.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Magnetic Resonance Imaging of the Musculoskeletal System at 7T: Morphological Imaging and Beyond.Topics in magnetic resonance imaging : TMRI · 2019Review
- Musculoskeletal imaging in preventive medicine.Wiener medizinische Wochenschrift (1946) · 2016Review
- [Functional MRI 2.0. ²³Na and CEST imaging].Der Radiologe · 2016Review
- New Imaging Methods for Non-invasive Assessment of Mechanical, Structural, and Biochemical Properties of Human Achilles Tendon: A Mini Review.Frontiers in physiology · 2016Review
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo determine if quantitative magnetic resonance (MR) imaging techniques (sodium MR imaging, glycosaminoglycan [GAG] chemical exchange saturation transfer [CEST], and T2* mapping) could be used as potential markers for biochemical changes in the Achilles tendon induced by ciprofloxacin intake. MATERIALS AND
methodsThe ethics committee of the Medical University of Vienna approved the protocol (number 1225/2012), and all patients gave written informed consent. Fourteen ankles from seven men (mean age, 32 years ± 12 [standard deviation]) were included in the study. All patients underwent 7-T MR imaging examinations of the Achilles tendon at baseline and 10 days and 5 months after ciprofloxacin intake. Sodium signal and T2* maps were acquired with the variable echo-time sequence and the GAG CEST values were acquired with a three-dimensional radiofrequency spoiled gradient-recalled-echo sequence.
resultsThe mean sodium signal was significantly decreased by 25% in the whole tendon (from baseline to 10 days after ciprofloxacin intake, 130 arbitrary units [au] ± 8 to 98 au ± 5, respectively; P = .023) and returned to baseline after 5 months (116 au ± 10), as observed also at the tendon insertion (baseline, 10 days after ciprofloxacin intake, and 5 months after ciprofloxacin intake, 134 au ± 8, 105 au ± 5, and 119 au ± 9, respectively; P = .034). The mean GAG CEST value in the whole tendon was parallel to the sodium signal with a decrease from baseline to 10 days after ciprofloxacin intake, 4.74% ± 0.75 to 4.50% ± 0.23, respectively (P = .028) and an increase at 5 months after ciprofloxacin intake to 4.88% ± 1.02.
conclusionIn conclusion, this study demonstrates a ciprofloxacin-induced reversible reduction of the normalized sodium MR imaging signal and the GAG CEST effect in the Achilles tendon of healthy volunteers. Changes in sodium MR imaging and GAG CEST in men may reflect a decrease of GAG content in the Achilles tendon after ciprofloxacin intake.
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