ArticleRadiology2015
Intravenous Iodinated Contrast Agents Amplify DNA Radiation Damage at CT.
Article in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 102 citations in OpenAlex.
- A prospective evaluation of contrast and radiation dose and image quality in cardiac CT in children with complex congenital heart disease using low-concentration iodinated contrast agent and low tube voltage and current.The British journal of radiology · 2017Trial
- Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients.Journal of radiation research · 2026Article
- Quantifying Radiation Effects of Iodinated Contrast Media in Pediatric CT Using DNA Damage Biomarkers.International journal of molecular sciences · 2026Article
- Article
- Assessment of Biological Damage Induced during Multidetector Computed Tomography (MDCT) Examination.Cell biochemistry and biophysics · 2024Article
- High-pitch CT pulmonary angiography (CTPA) with ultra-low contrast medium volume for the detection of pulmonary embolism: a comparison with standard CTPA.European radiology · 2024Article
- The Morphology of the Dorsal Part of the First Rib in Neurogenic Thoracic Outlet Syndrome Patients: A Retrospective Clinical Study.Journal of personalized medicine · 2024Article
- Radiation Doses in Cardiovascular Computed Tomography.Life (Basel, Switzerland) · 2023Review
- Initial experience on abdominal photon-counting computed tomography in clinical routine: general image quality and dose exposure.European radiology · 2023Article
- Vascular Mapping for Abdominal-Based Breast Reconstruction: A Comprehensive Review of Current and Upcoming Imaging Modalities.Eplasty · 2023Review
- Evaluation of selected parameters of inflammation, coagulation system, and formation of extracellular neutrophil traps (NETs) in the perioperative period in patients undergoing endovascular treatment of thoracoabdominal aneurysm with a branched device (t-Branch).Frontiers in cardiovascular medicine · 2023Article
- Multiplexed imaging in oncology.Nature biomedical engineering · 2022Review
- Relationship between Dilution Magnification of Non-Ionic Iodinated Contrast Medium and Amplification Effect of Radiation Dose.Journal of neuroendovascular therapy · 2022Article
- Potential increase in radiation-induced DNA double-strand breaks with higher doses of iodine contrast during coronary CT angiography.Medical physics · 2021Article
- The presence of contrast agent increases organ radiation dose in contrast-enhanced CT.European radiology · 2021Article
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [Cancers · 2020Article
- Application of Low Tube Potentials in CCTA: Results From the PROTECTION VI Study.JACC. Cardiovascular imaging · 2020Article
- Improved identification of DNA double strand breaks: γ-H2AX-epitope visualization by confocal microscopy and 3D reconstructed images.Radiation and environmental biophysics · 2019Article
- Ultra-low dose contrast CT pulmonary angiography in oncology patients using a high-pitch helical dual-source technology.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the effect of the use of iodinated contrast agents on the formation of DNA double-strand breaks during chest computed tomography (CT). MATERIALS AND
methodsThis study was approved by the institutional review board, and written informed consent was obtained from all patients. This single-center study was performed at a university hospital. A total of 179 patients underwent contrast material-enhanced CT, and 66 patients underwent unenhanced CT. Blood samples were taken from these patients prior to and immediately after CT. In these blood samples, the average number of phosphorylated histone H2AX (γH2AX) foci per lymphocyte was determined with fluorescence microscopy. Significant differences between the number of foci that developed in both the presence and the absence of the contrast agent were tested by using an independent sample t test.
resultsγH2AX foci levels were increased in both groups after CT. Patients who underwent contrast-enhanced CT had an increased amount of DNA radiation damage (mean increase ± standard error of the mean, 0.056 foci per cell ± 0.009). This increase was 107% ± 19 higher than that in patients who underwent unenhanced CT (mean increase, 0.027 foci per cell ± 0.014).
conclusionThe application of iodinated contrast agents during diagnostic x-ray procedures, such as chest CT, leads to a clear increase in the level of radiation-induced DNA damage as assessed with γH2AX foci formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.