ReviewVirulence2015
On the dynamics of root canal infections-what we understand and what we don't.
Review in Virulence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- When Novelty Outpaces Evidence: Social Media as an Unregulated Force Propelling Innovation in Endodontics: A Narrative Review.International endodontic journal · 2026Review
- An In Vitro Investigation of the Impact of Ultrasound Induced-Streaming Motions on the Flow Inside Lateral Features of the Root Canal.International endodontic journal · 2026Article
- Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report.Cureus · 2026Article
- Pulpitis as a microbial disease: single-cell insights into host responses and diagnostic biomarkers for vital pulp therapy.Journal of oral microbiology · 2026Review
- Profiling of microbes associated with chronic irreversible pulpitis using metagenomic next-generation sequencing.BMC oral health · 2025Article
- In Vitro Evaluation of Disinfectants on Gutta-Percha Cones: Antimicrobial Efficacy AgainstJournal of clinical medicine · 2025Article
- Periradicular Temperature Changes and Risk Management During Heat-Inducing Endodontic Disinfection Procedures In Vitro.Journal of clinical medicine · 2025Article
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Comparative Evaluation of Microtissue-Engineered Root Dentin with Three Different Nanoparticles in Improving Fatigue Resistance of Endodontically Treated Teeth - AnJournal of pharmacy & bioallied sciences · 2024Article
- Systemic Antibiotic Use in Acute Irreversible Pulpitis: Evaluating Clinical Practices and Molecular Insights.International journal of molecular sciences · 2024Review
- Profiling Antibiotic Susceptibility among DistinctAntibiotics (Basel, Switzerland) · 2023Article
- Nociceptor-Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain.Biomolecules · 2023Review
- Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review.Journal of clinical medicine · 2023Review
- Dual effectiveness of a novel all-in-one endodontic irrigating solution in antibiofilm activity and smear layer removal.Frontiers in bioengineering and biotechnology · 2023Article
- The presence ofFrontiers in cellular and infection microbiology · 2023Article
- Alternative Antibiotics in Dentistry: Antimicrobial Peptides.Pharmaceutics · 2022Review
- Article
- Patients with persistent idiopathic dentoalveolar pain in dental practice.International endodontic journal · 2022Observational
- A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research.International endodontic journal · 2022Review
- Clinical laboratory diagnostics in dentistry: Application of microbiological methods.Frontiers in oral health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections of the root canal space and their sequelae can be extremely painful and potentially dangerous, yet they do not necessarily have to be. Chronic, asymptomatic inflammatory lesions around the apex of a tooth with a necrotic dental pulp or an insufficient root canal treatment can develop unnoticed by the patient, and remain so for years. The course of disease is modulated by both the virulence of the microbiota established in the root canal space and the capacity of the immune system to curb the infection. To both ends, highly convincing investigations to help us understand when and why the tissues around an endodontically involved tooth become acutely inflamed are missing. We will discuss how recent advances in molecular identification of microorganisms have altered our understanding of root canal infections, and which information is currently missing to link clinical experience with observations from experimental research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.