ArticleTheScientificWorldJournal2014
Single nucleotide polymorphisms in microRNA binding sites: implications in colorectal cancer.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Association of ACE2 gene polymorphisms with risk of pulmonary arterial hypertension in neonates with congenital heart disease.BMC cardiovascular disorders · 2026Article
- Genetic variants in mitochondrial sirtuins associated with brain tumor risk: a case-control study.Future oncology (London, England) · 2024Article
- Structural modifications and kinetic effects ofFrontiers in molecular biosciences · 2024Article
- The Enrichment of miRNA-Targeted mRNAs in Translationally Less Active over More Active Polysomes.Biology · 2023Article
- Roles of phosphatidylinositol-3-kinases signaling pathway in inflammation-related cancer: Impact of rs10889677 variant and buparlisib in colitis-associated cancer.World journal of gastroenterology · 2023Article
- Single nucleotide polymorphisms in microRNA binding sites on theBiochemistry and biophysics reports · 2021Article
- Development and validation of a clinicopathological-based nomogram to predict seeding risk after percutaneous thermal ablation of primary liver carcinoma.Cancer medicine · 2020Article
- Article
- Circulating Extracellular Vesicle MicroRNA as Diagnostic Biomarkers in Early Colorectal Cancer-A Review.Cancers · 2019Review
- Identification of key candidate genes and miRNA‑mRNA target pairs in chronic lymphocytic leukemia by integrated bioinformatics analysis.Molecular medicine reports · 2019Article
- Single nucleotide polymorphism rs4648298 in miRNAs hsa-miR21 and hsa-miR590 binding site ofJournal of gastrointestinal oncology · 2018Article
- The role of lncRNA CASC2 on prognosis of malignant tumors: a meta-analysis and bioinformatics.OncoTargets and therapy · 2018Article
- A 5-serum miRNA panel for the early detection of colorectal cancer.OncoTargets and therapy · 2018Article
- Article
- FAM172A expression in circulating tumor cells for prediction of high-risk subgroups of colorectal cancer.OncoTargets and therapy · 2017Article
- Polymorphism (rs16917496) at the miR-502 Binding Site of the Lysine Methyltransferase 5A (Advanced biomedical research · 2017Article
- Let-7b Regulates Myoblast Proliferation by InhibitingFrontiers in physiology · 2017Article
- Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients.Medicine · 2016Article
- Identification of colorectal cancer-restricted microRNAs and their target genes based on high-throughput sequencing data.OncoTargets and therapy · 2016Article
- The expression and significance of Gal-3 and MUC1 in colorectal cancer and colon cancer.OncoTargets and therapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a complex genetic disorder, characterised by uncontrolled cell proliferation and caused by altered expression of oncogenes and tumour suppressor genes. When cell proliferation pertains to colon, it is called colorectal cancer. Most of colorectal cancer causing genes are potential targets for the miRNA (microRNA) that bind to 3'UTR (untranslated regions) of mRNA and inhibit translation. Mutations occurring in miRNA binding regions can alter the miRNA, mRNA combination, and can alter gene expression drastically. We hypothesized that 3'UTR mutation in miRNA binding site could alter the miRNA, mRNA interaction, thereby altering gene expression. Altered gene expression activity could promote tumorigenesis in colon. Therefore, we formulated a systematic in silico procedure that integrates data from various databases, followed rigorous selection criteria, and identified mutations that might alter the expression levels of cancer causing genes. Further we performed expression analysis to shed light on the potential tissues that might be affected by mutation, enrichment analysis to find the metabolic functions of the gene, and network analysis to highlight the important interactions of cancer causing genes with other genes to provide insight that complex network will be disturbed upon mutation. We provide in silico evidence for the effect of these mutations in colorectal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.