Evidence map›Paper›PMID 25653946›Full record

ArticleJournal of clinical and diagnostic research : JCDR2014

Prevalence of Community-Acquired Methicillin-Resistant Staphylococcus aureus Nasal Colonization Among Children.

Veena Shetty, Katherine Trumbull, Amitha Hegde, Vijaya Shenoy, Raghavendra Prabhu, Sumathi K, Elizabeth Palavecino, Avinash K Shetty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Nasal Carriage and Methicillin Resistance ofInternational journal of microbiology · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Prevalence of nasal colonization of methicillin-resistantJournal of family medicine and primary care
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Veena ShettyAssociate Professor, Department of Microbiology, K.S. Hegde Medical Academy, Nitte University , Karnataka, India .
Katherine TrumbullMedical Student, Wake Forest School of Medicine , Winston-Salem, NC .
Amitha HegdeHead of Department, Department of Pedodontics, K.S. Hegde Medical Academy, Nitte University , Karnataka, India .
Vijaya ShenoyHead of Department, Department of Pediatrics, K.S. Hegde Medical Academy , Nitte University, Karnataka, India .
Raghavendra PrabhuAssociate Professor, Department of Pediatrics, K.S. Hegde Medical Academy, Nitte University , Karnataka, India .
Sumathi KLecturer, Department of Statistics, K.S. Hegde Medical Academy, Nitte University , Karnataka, India .
Elizabeth PalavecinoDirector Clinical Microbiology, Department of Pathology, Wake Forest School of Medicine , Winston-Salem, NC .
Avinash K ShettyProfessor, Department of Pediatrics, Wake Forest School of Medicine , Winston-Salem, NC .
K S Hegde Medical Academy · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive infections from community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly being encountered in healthy children. Nasal colonization of MRSA is associated with increased risk for acquiring invasive disease. The objective of this study was to determine prevalence and risk factors for CA-MRSA nasal colonization among a healthy paediatric population and to determine antibiotic susceptibilities of S. aureus isolates. MATERIALS AND

methodsUsing a cross-sectional study design, children aged 1mnth-17y attending well-child clinic at an academic hospital and a local public school in Mangalore, India were screened for S. aureus colonization via nasal swabs. A questionnaire was administered and data on risk factors for nasal colonization was collected. Samples were obtained from the anterior nares and cultured quantitatively. S. aureus isolates were confirmed by growth on selective media and coagulase testing. Disk diffusion antibiotic susceptibility tests were performed according to Clinical and Laboratory Standard Institute guidelines.

resultsOf the 500 children included in the study, S. aureus was isolated from the anterior nares in 126 (25%) children; four (3%) isolates were classified as CA-MRSA. Factors associated with S. aureus nasal colonization were children <6 y old (p=0.030) and members of joint families (p=0.044). Resistance to many classes of antibiotics were noted among S. aureus isolates including trimethoprim-sulfamethoxazole (39%), ciprofloxacin (16%), erythromycin (19%) and clindamycin (5%). Inducible clindamycin resistance (positive D test) was detected in 11 of the erythromycin-resistant strains not already classified as resistant to clindamycin. No resistance to vancomycin was observed.

conclusionChildren in India have a high rate of nasal colonization of S. aureus. Nasal colonization of community-associated methicillin-resistant S. aureus exists but is still low among healthy children. The high rate of resistance to many classes of antibiotics among S. aureus strains is of great concern warranting continued surveillance and antimicrobial stewardship.

Indexed as

ChildrenDisk diffusion testKarnatakaNasal carriageStaphylococcus aureus

Identifiers

PMID25653946
PMCPMC4316252
OpenAlexW2168621619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.