ReviewPeerJ2015
The physiologic and therapeutic role of heparin in implantation and placentation.
Review in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05237843 (Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Low-molecular-weight heparin in the prevention of unexplained recurrent miscarriage: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Pregnancy and thrombosis risk for women without a history of thrombotic events: a retrospective study of the real risks.Thrombosis journal · 2022Article
- Article
- Article
- A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood.Biomolecules · 2020Article
- Trophoblast-Derived CXCL16 Decreased Granzyme B Production of Decidual γδ T Cells and Promoted Bcl-xL Expression of Trophoblasts.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature.Thrombosis journal · 2019Article
- Systemic administration of heparin ameliorates radiation-induced oral mucositis-preclinical studies in mice.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins.Blood advances · 2017Article
- Heparin-Mimicking Polymers: Synthesis and Biological Applications.Biomacromolecules · 2016Review
- The presence of heparins during decidualization modulates the response of human endometrial stromal cells to IL-1β in vitro.Journal of assisted reproduction and genetics · 2016Article
- Adverse obstetric outcomes in pregnancies resulting from oocyte donation: a retrospective cohort case study in Sweden.BMC pregnancy and childbirth · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, preterm labor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.