ArticleAdvances in orthopedics2015
The use of a dehydrated amnion/chorion membrane allograft in patients who subsequently undergo reexploration after posterior lumbar instrumentation.
Article in Advances in orthopedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03754218 (Phase 1 Study of Human Amnion Membrane Powder for Enhanced Wound Healing), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 1 Study of Human Amnion Membrane Powder for Enhanced Wound Healing
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Dehydrated human amniotic membrane for early return of erectile function after robotic radical prostatectomy: a 10-year journey and lessons learned.Journal of robotic surgery · 2026Article
- Effectiveness of epidural amniotic fluid injection for low back pain.Interventional pain medicine · 2025Article
- Human amniotic membrane modulates collagen production and deposition in vitro.Scientific reports · 2024Article
- Assessing placental membrane treatment efficiency in diabetic foot ulcers: Processing for retention versus lamination.Health science reports · 2024Article
- Clinico-radiological outcome of Arthroscopic Anterior Cruciate Ligament Reconstruction with Augmentation of Dehydrated Human Amnion Chorion Allograft Membrane using Peroneus Longus Autograft.Malaysian orthopaedic journal · 2024Article
- The Effect of Amniotic Tissue on Spinal Interventions: A Systematic Review.International journal of spine surgery · 2023Article
- Amniotic membrane attenuates heterotopic ossification following high-dose bone morphogenetic protein-2 treatment of segmental bone defects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Human Amniotic Membrane Wrapping of the Ulnar Nerve During Cubital Tunnel Surgery Reduces Recurrence of Symptoms.The archives of bone and joint surgery · 2022Article
- Standardized reporting of amnion and amnion/chorion allograft data for wound care.Health science reports · 2022Article
- Interposition of human amniotic membrane at the bone-tendon interface of a full-thickness rotator cuff repair.JSES reviews, reports, and techniques · 2022Article
- Orthobiologic Supplementation Improves Clinical Outcomes Following Lumbar Decompression Surgery.Journal of clinical medicine research · 2020Article
- Evaluation of two distinct placental-derived membranes and their effect on tenocyte responses in vitro.Journal of tissue engineering and regenerative medicine · 2019Article
- A matched and controlled longitudinal cohort study of dehydrated human amniotic membrane allograft sheet used as a wraparound nerve bundles in robotic-assisted laparoscopic radical prostatectomy: a puissant adjunct for enhanced potency outcomes.Journal of robotic surgery · 2019Article
- Novel Role of Dehydrated Human Amnion/Chorion Membrane in Healing of Denuded Ureter in Robot-Assisted Excision of Endometriosis.Case reports in obstetrics and gynecology · 2019Article
- The Science and Clinical Applications of Placental Tissues in Spine Surgery.Global spine journal · 2018Review
- The Use of Dehydrated Amniotic Membrane Allograft for the Augmentation of Dural Repair in Craniotomies.Cureus · 2018Article
- Amniotic therapeutic biomaterials in urology: current and future applications.Translational andrology and urology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Context. Products that can reduce development of epidural fibrosis may reduce risk for ongoing pain associated with development of scar tissue and make subsequent epidural reexploration easier. Purpose. To evaluate the use of dehydrated human amnion/chorion membrane (dHACM) on the formation of soft tissue scarring in the epidural space. Study Design. Case series. Patient Sample. Five patients having transforaminal lumbar interbody lumbar fusion (TLIF) with posterior instrumentation and implantation of dHACM in the epidural space and subsequent epidural reexploration. Outcome Measures. Degree of scar tissue adjacent to the epidural space at reexploration. Intraoperative and postoperative complications related to dHACM and patient reported outcomes. Methods. The degree of scar tissue adjacent to the epidural space was assessed during the reexploration surgery. Patients' outcomes were collected using standard validated questionnaires. Results. Four of 5 cases had easily detachable tissue during epidural reexploration. Angiolipoma of 10% was noted in 1 case and 5% in 2 cases. Significant improvements in patient reported outcomes were observed. No intraoperative or postoperative complications occurred. Conclusions. Our findings suggest that dHACM implant during TLIF may have favorable effects on epidural fibrosis and is well tolerated. Further studies with larger cohorts are required to prove our results.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.