ArticleTherapeutic advances in psychopharmacology2015
Reducing the rates of prescribing high-dose antipsychotics and polypharmacy on psychiatric inpatient and intensive care units: results of a 6-year quality improvement programme.
Article in Therapeutic advances in psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Prescription patterns in psychiatric compulsory care: polypharmacy and high-dose antipsychotics.BJPsych open · 2021Article
- Drug-naïve first-episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China.Early intervention in psychiatry · 2021Article
- Antipsychotic Polypharmacy and High-Dose Antipsychotics in Involuntary Patients: a Seven-Year Audit of Discharge Prescriptions in an Acute Care Unit.The Psychiatric quarterly · 2021Article
- Risk Factors of Metabolic Syndrome Among Patients Receiving Antipsychotics: A Retrospective Study.Community mental health journal · 2020Article
- Antipsychotics and risk of natural death in patients with schizophrenia.Neuropsychiatric disease and treatment · 2019Article
- Predicting parkinsonism side-effects of antipsychotic polypharmacy prescribed in secondary mental healthcare.Journal of psychopharmacology (Oxford, England) · 2018Article
- Long-term antipsychotic polypharmacy prescribing in secondary mental health care and the risk of mortality.Acta psychiatrica Scandinavica · 2018Article
- Antipsychotic polypharmacy prescribing and risk of hospital readmission.Psychopharmacology · 2018Observational
- Antipsychotic prescribing for vulnerable populations: a clinical audit at an acute Australian mental health unit at two-time points.BMC psychiatry · 2017Article
- Implementation of a clinical practice guideline for schizophrenia in a specialist mental health center: an observational study.BMC health services research · 2016Observational
- Predictors of long-term (≥6months) antipsychotic polypharmacy prescribing in secondary mental healthcare.Schizophrenia research · 2016Article
- Factors associated with non evidence-based prescribing of antipsychotics.Therapeutic advances in psychopharmacology · 2014Article
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2 authors.
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Abstract
backgroundThere is no conclusive evidence that either high doses or combinations of antipsychotics are more effective than standard doses or monotherapy alone. Nonetheless, prescription of both remains prevalent in the UK. In 2006 the South London and Maudsley NHS Foundation Trust (SLAM) participated in a national survey of prescription of antipsychotic medications, organized by the Prescribing Observatory for Mental Health. Over half of the patients on SLAM inpatient or psychiatric intensive care units were prescribed a high-dose antipsychotic or a combination of antipsychotics. Prescribing high-dose antipsychotics and polypharmacy in SLAM was found to be among the highest in the UK.
aimTo assess the impact of a 6-year quality improvement programme aimed at reducing the rates of prescribing high-dose antipsychotics and polypharmacy on SLAM inpatients and psychiatric intensive care units.
resultsThere was a significant reduction between baseline and final survey in the rates of prescription of both high-dose antipsychotics and polypharmacy on SLAM inpatients and intensive care units (58% versus 10% p < 0.0001 and 57% versus 16%, p < 0.0001 respectively). The proportion of patients at final survey prescribed a high-dose antipsychotic and a combination was substantially lower in SLAM than in the national sample (10% versus 28%, p < 0.0001 and 16% versus 38%, p < 0.0001 respectively). CLINICAL IMPLICATIONS: A sustained change in the prescribing culture of an organization can be achieved through a targeted improvement programme.
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