Evidence map›Paper›PMID 25653803›Full record

ArticleJournal of lasers in medical sciences2014

One Possible Mechanism of Pulsed Dye Laser Treatment on Infantile Hemangioma: Induction of Endothelial Apoptosis and Serum vascular endothelial growth factor (VEGF) Level Changes.

Yongqian Cao, Fagang Wang, Qingwei Jia, Rongjian Xu, Wei Dang, Qing Chen, Li Lin, Yibing Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of lasers in medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yongqian CaoDepartment of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Fagang WangDepartment of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Qingwei JiaDepartment of Orthopedics Affiliated Hospital of Taishan Medical Univisity, Shandong, P R China.
Rongjian XuDepartment of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Wei DangDepartment of Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University, Shandong, P R China.
Qing ChenDepartment of Endocrinology, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Li LinDepartment of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Yibing WangDepartment of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Shandong, P R China.
Shandong Provincial Hospital · CNAffiliated Hospital of Taishan Medical University · CNJinan Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPulsed dye laser (PDL) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. The aim of this study was to evaluate alterations of serum vascular endothelial growth factor (VEGF) level in infantile hemangioma (IH) patients after laser treatment and effects of PDL irradiation on human umbilical vein endothelial cells (HUVECs) in vitro, as well as to explore the biomolecular mechanisms and ultrastructure changes of the PDL effect.

methods74 children with infant hemangioma including 45 patients in proliferating phase, 18 patients in involuting phase, 11 patients in involuted phase and 10 healthy children were engaged in this study. The plasma VEGF levels of children were measured with the enzymelinked immunosorbent assay (ELISA). 24 hours after, HUVECs cultured in vitro were irradiated with PDL, cell apoptosis, mRNA levels of VEGF, and changes of ultrastructure were evaluated using flow cytometry, real-time reverse transcriptase polymerase chain reaction (RT-PCR), and transmission electron microscopy, respectively.

resultsThe serum VEGF concentrations in children with proliferating hemangiomas were significantly higher than in patients with involuting / involved hemangiomas and healthy patients. After receiving 3 laser treatments, the plasma VEGF levels of IH patients in proliferating hemangiomas decreased significantly. PDL irradiation could down-regulate VEGF mRNA expression of HUVECs, and increase cell apoptosis rate.

conclusionThe present study demonstrates that PDL irradiation imparts apoptosis induction effects on HUVECs in vitro. Furthermore, our results suggest that vascular endothelial growth factor may be of particular importance in pathophysiology and PDL treatment of hemangiomas, also serum VEGF levels may be used as an aid in the follow up of IH. This provides valuable evidence of the PDL effect on infantile hemangioma.

Indexed as

apoptosisinfantile hemangiomapulsed dye lasersvascular endothelial growth factor

Identifiers

PMID25653803
PMCPMC4291820
OpenAlexW2109250966

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.