Evidence map›Paper›PMID 25653800›Full record

ReviewJournal of lasers in medical sciences2014

Biological effects of low level laser therapy.

Shirin Farivar, Talieh Malekshahabi, Reza Shiari

4 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Journal of lasers in medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 206 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 10 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04165226 nacompletednot on this mapstarted 2018, after this paper: background citation

Low Level Light Therapy and Fractional Carbon Dioxide Laser in the Treatment of Stria Alba: A Randomised Controlled Study

TypeinterventionalSponsorKasr El Aini HospitalRan2018 to 2019Enrolled30ConditionsStriae, AlbicantesArmsLow level light therapy, Fractional CO2, Combined fractional CO2 laser and low level light therapy
NCT05695053 early_phase1completednot on this mapstarted 2021, after this paper: background citation

Low Level Laser Therapy Applied in Orthodontic Tooth Movement

TypeinterventionalSponsorChina Medical University HospitalRan2021 to 2023Enrolled20ConditionsOrthodontic Appliance ComplicationArmsLow Level Laser Therapy, Placebo
NCT05992233 nacompletednot on this mapstarted 2021, after this paper: background citation

Is Dual-wavelength Low-level Laser Therapy Effective in Reducing Pain, Swelling and Trismus After Impacted Mandibular Third Molar Extraction?

TypeinterventionalSponsorTokat Gaziosmanpasa UniversityRan2021 to 2022Enrolled40ConditionsMolar, Third, Low-level Laser TherapyArmsDual wavelength low level laser, Placebo
NCT07287046 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Comparison of Efficacy Between High-intensity Laser Therapy and Focused Extracorporeal Shock Wave Therapy in Patient With Plantar Fasciitis; Single Blinded Randomize Controlled Study

TypeinterventionalSponsorMahidol UniversityRan2026 to 2027Enrolled28ConditionsPlantar FasciitisArmsHigh power Laser therapy, Focused extracorporeal shock wave therapy
3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 10 syntheses or guidelines pooled it, 409 citations in OpenAlex.

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  15. Type of study: original study.Lasers in medical science · 2025
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  17. Enhanced Recovery of Local Anesthesia in Pediatric Patients: The Impact of Photobiomodulation on Reversing Anesthesia Effects.Medical science monitor : international medical journal of experimental and clinical research · 2024
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shirin FarivarDepartment of Genetics, Faculty of Biological Science, Shahid Beheshti University (GC), Tehran, Iran.
Talieh MalekshahabiDepartment of Genetics, Faculty of Biological Science, Shahid Beheshti University (GC), Tehran, Iran.
Reza ShiariDepartmentof Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of low level laser to reduce pain, inflammation and edema, to promote wound, deeper tissues and nerves healing, and to prevent tissue damage has been known for almost forty years since the invention of lasers. This review will cover some of the proposed cellular mechanisms responsible for the effect of visible light on mammalian cells, including cytochrome c oxidase (with absorption peaks in the Near Infrared (NIR)). Mitochondria are thought to be a likely site for the initial effects of light, leading to increased ATP production, modulation of reactive oxygen species, and induction of transcription factors. These effects in turn lead to increased cell proliferation and migration (particularly by fibroblasts).

Indexed as

cell migrationcell proliferationcytochrome c oxidaselow level laser therapyreactive oxygen species

Identifiers

PMID25653800
PMCPMC4291815
OpenAlexW2141285655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.