Evidence map›Paper›PMID 25653674›Full record

ArticleIranian journal of reproductive medicine2015

Association between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population.

Dandan Li, Junjie Cheng, Wanghong Li, Wei Ma, Xu Zhou, Lianwen Zheng, Chunjin Li

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dandan LiThe Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China.
Junjie ChengThe Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China.
Wanghong LiCollege of Animal Sciences, Jilin University, 5333 Xi'an Avenue, Changchun, Jilin Province, 130062, China.
Wei MaCollege of Animal Science and Veterinary Medicine, Liaoning Medical University, Jinzhou, Liaoning, China.
Xu ZhouCollege of Animal Sciences, Jilin University, 5333 Xi'an Avenue, Changchun, Jilin Province, 130062, China.
Lianwen ZhengThe Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China.
Chunjin LiCollege of Animal Sciences, Jilin University, 5333 Xi'an Avenue, Changchun, Jilin Province, 130062, China.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CNJinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. Investigations have showed that polymorphism of progesterone receptor (PGR) is associated with some diseases.

objectiveTo analyze the potential relationship between male infertility and the +331G/A and progins polymorphisms of PGR gene. MATERIALS AND

methodsThe cross-sectional study was carried out at the Department of Male Reproduction, Reproductive Medical Center, the Second Hospital of Jilin University. The restriction fragment length polymorphism (RFLP) technique was used to detect gene point mutations. Of the 145 semen samples analyzed, 35 were asthenozoospermic, 50 were oligoasthenozoospermic, 21 were azoospermic, 11 were teratozoospermic and 28 were from fertile male subjects.

resultsStatistical analyses revealed that the genotypes of the +331G/A polymorphisms were in Hardy-Weinberg equilibrium in both the fertile ((2)=0, p=0.534) and oligospermic groups ((2)=0.021, p=0.537). Similarly, the genotypes of the progins polymorphisms were also in Hardy-Weinberg equilibrium in both the fertile ((2)=0, p=1) and oligospermic groups ((2)=0.005, p=1).

conclusionOur results indicated that polymorphisms of the +331G/A and progins of the PGR gene are unrelated to male infertility, at least in a Chinese population.

Indexed as

+331G/A polymorphismMale infertilityProgesterone receptorProgins polymorphism

Identifiers

PMID25653674
PMCPMC4306983
OpenAlexW2319745984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.