ArticleIranian journal of reproductive medicine2015
Royal Jelly alleviates sperm toxicity and improves in vitro fertilization outcome in Stanozolol-treated mice.
Article in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Use of black seed (Nigella sativa) honey bee to improve sheep oocyte maturation medium.Environmental science and pollution research international · 2020Article
- Protective effect of vitamin E on sperm quality andVeterinary research forum : an international quarterly journal · 2020Article
- Attenuation potentials of royal jelly against hydroxyurea-induced infertility through inhibiting oxidation and release of pro-inflammatory cytokines in male rats.Environmental science and pollution research international · 2019Article
- Royal jelly protects male mice against nicotine-induced reproductive failure.Veterinary research forum : an international quarterly journal · 2018Article
- Comparative study of the protective effects of chicken embryo amniotic fluid, vitamin C and coenzyme Q10 on cyclophosphamide-induced oxidative stress in mice ovaries.Veterinary research forum : an international quarterly journal · 2018Article
- Determination of DNA damage and telomerase activity in stanozolol-treated rats.Experimental and therapeutic medicine · 2017Article
- Effects of bisphenol-S low concentrations on oxidative stress status andVeterinary research forum : an international quarterly journal · 2017Article
- Ameliorative effects ofVeterinary research forum : an international quarterly journal · 2017Article
- Urolithin A safeguards against diabetes-induced pathospermia and embryotoxicity in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStanozolol (ST) is a synthetic anabolic-androgenic steroid often abused by athletes. An increasing body of evidence points towards the role of ST misuses in the pathogenesis of a wide range of adverse effects including reprotoxicity.
objectiveThe aim of this study was to analyze the possible reproprotective effect of royal jelly (RJ) as an efficient antioxidant in ST-treated mice. MATERIALS AND
methodsAdult male mice were divided into four groups (n=5). Two groups of mice received ST (4.6 mg/kg/day) via gavage for 35 days. RJ was given orally to one of these groups at the dose level of 100 mg/kg body weight per day synchronously. Untreated control group and RJ-only treated group were also included. Epididymal sperm characteristics and in vitro fertilizing capacity were evaluated after 35 days.
resultsST treatment caused a significant (p<0.05) decrease in sperm count and motility and fertilization rate along with poor blastocyst formation and increased sperm DNA damage. Moreover, the incidence of apoptosis and abnormality in spermatozoa was significantly (p<0.05) higher in ST-exposed mice than those of control. The above-mentioned parameters were restored to near normal level by RJ co-administration.
conclusionData from the current study suggest that RJ has a potential repro-protective action against ST-induced reproductive toxicity in mice. However, clinical studies are warranted to investigate such an effect in human subjects.
Indexed as
Identifiers
25653671PMC4306980W2187166174What OpenQuestion holds
Registered trials
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