ArticleFrontiers in microbiology2014
Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Bioactive Secondary Metabolites from an Arctic Marine-Derived Strain,Molecules (Basel, Switzerland) · 2025Article
- Optimization and characterization of bioactive secondary metabolites from Streptomyces sp CMSTAAHL-4 isolated from mangrove sediment.BMC microbiology · 2025Article
- Identification, fermentation optimization, and biocontrol efficacy of actinomycete YG-5 for the prevention of Alternaria leaf spot disease in star anise.Scientific reports · 2024Article
- A statistical approach to enhance the productivity of Streptomyces baarensis MH-133 for bioactive compounds.Synthetic and systems biotechnology · 2024Article
- Biodiversity and Bioactive Potential of Actinomycetes from Unexplored High Altitude Regions of Kargil, India.Indian journal of microbiology · 2024Article
- Optimizing the production and efficacy of antimicrobial bioactive compounds fromFrontiers in cellular and infection microbiology · 2024Article
- Effect of the Nanoparticle Exposures on the Tomato Bacterial Wilt Disease Control by Modulating the Rhizosphere Bacterial Community.International journal of molecular sciences · 2021Article
- Production strategies and biotechnological relevance of microbial lipases: a review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Production of a broad spectrum streptothricin like antibiotic from halotolerant Streptomyces fimbriatus isolate G1 associated with marine sediments.Folia microbiologica · 2021Article
- Biosynthetic Potential ofAntibiotics (Basel, Switzerland) · 2021Article
- Low-cost media engineering for phosphate and IAA production by3 Biotech · 2021Article
- Enhancement of Antibacterial Activity ofBioMed research international · 2020Article
- Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety.AMB Express · 2019Article
- Anti-MRSA activity of a bioactive compound produced by a marineIranian journal of basic medical sciences · 2019Article
- Article
- Statistical optimization of culture medium for improved production of antimicrobial compound byFood science and biotechnology · 2018Article
- Screening and Whole-Genome Sequencing of TwoBioMed research international · 2018Article
- Article
- Antagonistic Properties of Some Halophilic Thermoactinomycetes Isolated from Superficial Sediment of a Solar Saltern and Production of Cyclic Antimicrobial Peptides by the Novel IsolateBioMed research international · 2017Article
- Strategies for Fermentation Medium Optimization: An In-Depth Review.Frontiers in microbiology · 2016Review
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4 authors.
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Abstract
A moderately halotolerant Streptomyces strain, designated JAJ13 was characterized and a culture medium was statistically optimized to improve its antibacterial activity. Based on the phenotypic and molecular characteristics, strain JAJ13 was identified as a moderately halotolerant Streptomyces sp. JAJ13. Novelty of the strain JAJ13 in production of antibacterial compound was assessed by sequence analysis of KSα gene and LC-MS analysis of the active compound. Optimization of the culture medium for antibacterial compound production by the strain JAJ13 was performed with statistical methodology based on experimental designs. Initially, a starch based basal production medium was selected out of eight different production media screened for antibacterial compound production by Streptomyces sp. JAJ13. Plackett-Burman design was employed to screen the influential media components affecting the antibacterial compound production. Subsequently, statistical optimization of selected medium components was performed by employing the response surface methodology (RSM) with Box-Behnken design. The optimum initial level of CuSO4.5H2O, (NH4)2SO4 and K2HPO4 for the highest antibacterial activity was determined to be at 4.45 mg, 1.96 g, and 1.15 g in 1 L of distilled H2O, respectively. PBD and RSM guided design of experiments resulted in a maximum antibacterial activity of 23.37 ± 2.08 mm, which is a 78.8% increase in comparison with that obtained in the unoptimized medium. This study points the success of statistical model in developing an optimized production media for enhanced antibacterial compound production by Streptomyces sp. JAJ13.
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