ArticleFrontiers in psychology2014
Maladaptive autonomic regulation in PTSD accelerates physiological aging.
Article in Frontiers in psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of Associations Between Interoception, Vagal Tone, and Emotional Regulation: Potential Applications for Mental Health, Wellbeing, Psychological Flexibility, and Chronic Conditions.Frontiers in psychology · 2020Pooled it
- Traumatic stress and accelerated DNA methylation age: A meta-analysis.Psychoneuroendocrinology · 2018Pooled it
- Feasibility study examining the short-term effects of Sonic Augmentation Technology™.Frontiers in psychiatry · 2026Trial
- Understanding emotion dysregulation in PTSD - GAD comorbidity.Journal of anxiety disorders · 2025Trial
- Heart Rate Variability Features as Predictors of Intermittent Theta-Burst Stimulation Response in Posttraumatic Stress Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2022Trial
- Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post-traumatic stress disorder.Experimental physiology · 2026Article
- A new paradigm for defining trauma: bridging interdisciplinary perspectives.Frontiers in psychology · 2026Article
- Sex dependency of subconscious visual perception.Biology of sex differences · 2025Article
- Inflammatory, White Matter, and Neurodegenerative Mechanisms in Fluid Ability Decrements in Chronic Mild-to-Moderate Traumatic Brain Injury.Journal of neurotrauma · 2025Article
- Transcutaneous vagal nerve stimulation for the treatment of trauma- and stressor-related disorders: systematic review of randomised controlled studies.BJPsych open · 2025Review
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Understanding the Role of Loneliness in the Relationships Between Post-Traumatic Stress Symptoms and Both Anxiety and Depressive Symptoms Among University Students: A Mediation Analysis.Brain sciences · 2025Article
- Article
- Epigenetic Age Acceleration and Disparities in Posttraumatic Stress in Women in Southeast Louisiana: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- The Influence of Social Dynamics on Biological Aging and the Health of Historically Marginalized Populations: A Biopsychosocial Model for Health Disparities.International journal of environmental research and public health · 2024Review
- Metabolic Profile and Long-Term Risk of Depression, Anxiety, and Stress-Related Disorders.JAMA network open · 2024Article
- Differing associations of depersonalization with physiological response during rest and breath-focused mindfulness in a trauma-exposed female population.Journal of psychiatric research · 2023Article
- Prospective examination of psychological trauma among adolescents during the COVID-19 pandemic.Psychological trauma : theory, research, practice and policy · 2023Article
- Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.International journal of geriatric psychiatry · 2023Article
- Peritraumatic physical symptoms and the clinical trajectory of PTSD after a terrorist attack: a network model approach.European journal of psychotraumatology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A core manifestation of post-traumatic stress disorder (PTSD) is a disconnection between physiological state and psychological or behavioral processes necessary to adequately respond to environmental demands. Patients with PTSD experience abnormal oscillations in autonomic states supporting either fight and flight behaviors or withdrawal, immobilization, and dissociation without an intervening "calm" state that would provide opportunities for positive social interactions. This defensive autonomic disposition is adaptive in dangerous and life threatening situations, but in the context of every-day life may lead to significant psychosocial distress and deteriorating social relationships. The perpetuation of these maladaptive autonomic responses may contribute to the development of comorbid mental health issues such as depression, loneliness, and hostility that further modify the nature of cardiovascular behavior in the context of internal and external stressors. Over time, changes in autonomic, endocrine, and immune function contribute to deteriorating health, which is potently expressed in brain dysfunction and cardiovascular disease. In this theoretical review paper, we present an overview of the literature on the chronic health effects of PTSD. We discuss the brain networks underlying PTSD in the context of autonomic efferent and afferent contributions and how disruption of these networks leads to poor health outcomes. Finally, we discuss treatment approaches based on our theoretical model of PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.