Evidence map›Paper›PMID 25653613›Full record

ArticleFrontiers in computational neuroscience2014

Spatial information in large-scale neural recordings.

Thaddeus R Cybulski, Joshua I Glaser, Adam H Marblestone, Bradley M Zamft, Edward S Boyden, George M Church, Konrad P Kording

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. CHIME: CMOS-HostedFrontiers in neuroscience · 2020
    Article
  3. Nucleotide-time alignment for molecular recorders.PLoS computational biology · 2017
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thaddeus R CybulskiDepartment of Physical Medicine and Rehabilitation, Rehabilitation Institute of Chicago, Northwestern University Chicago, IL, USA.
Joshua I GlaserDepartment of Physical Medicine and Rehabilitation, Rehabilitation Institute of Chicago, Northwestern University Chicago, IL, USA.
Adam H MarblestoneBiophysics Program, Harvard University Boston, MA, USA ; Wyss Institute, Harvard University Boston, MA, USA.
Bradley M ZamftDepartment of Genetics, Harvard Medical School, Harvard University Boston, MA, USA.
Edward S BoydenMedia Lab, Massachusetts Institute of Technology Cambridge, MA, USA ; Department of Biological Engineering, Massachusetts Institute of Technology Cambridge, MA, USA ; McGovern Institute, Massachusetts Institute of Technology Cambridge, MA, USA.
George M ChurchBiophysics Program, Harvard University Boston, MA, USA ; Wyss Institute, Harvard University Boston, MA, USA ; Department of Genetics, Harvard Medical School, Harvard University Boston, MA, USA.
Konrad P KordingDepartment of Physical Medicine and Rehabilitation, Rehabilitation Institute of Chicago, Northwestern University Chicago, IL, USA ; Department of Physiology, Northwestern University Chicago, IL, USA ; Department of Applied Mathematics, Northwestern University Chicago, IL, USA.

Funding

Transformation of Planned Hand Movements into Motor Commands by the Motor CortexP01NS044393 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GRAFTON, SCOTT THOMAS · 2003 to 2013
$12.2M
Recording neural activities onto DNAR01MH103910 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BOYDEN, EDWARD S., CHURCH, GEORGE M · 2013 to 2017
$9.5M
Redesigning General Anesthesia (Admin Supp)R01GM104948 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., BROWN, EMERY N · 2012 to 2016
$4.4M
Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and DiseaseDP1NS087724 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2013 to 2017
$3.9M
The role of uncertainty in human motor learning and adaptationR01NS063399 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KORDING, KONRAD P. · 2009 to 2019
$2.8M
The representation of uncertainty in the sensorimotor systemR01NS074044 · NINDS · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI KORDING, KONRAD P., MILLER, LEE · 2011 to 2015
$1.6M
NIGMS NIH HHS R01 GM104948NIMH NIH HHS R01 MH103910NINDS NIH HHS DP1 NS087724NINDS NIH HHS P01 NS044393NINDS NIH HHS R01 NS063399NINDS NIH HHS R01 NS074044
6 · The paper itself

Abstract

To record from a given neuron, a recording technology must be able to separate the activity of that neuron from the activity of its neighbors. Here, we develop a Fisher information based framework to determine the conditions under which this is feasible for a given technology. This framework combines measurable point spread functions with measurable noise distributions to produce theoretical bounds on the precision with which a recording technology can localize neural activities. If there is sufficient information to uniquely localize neural activities, then a technology will, from an information theoretic perspective, be able to record from these neurons. We (1) describe this framework, and (2) demonstrate its application in model experiments. This method generalizes to many recording devices that resolve objects in space and should be useful in the design of next-generation scalable neural recording systems.

Indexed as

electrical recordingextracellular recordingfisher informationneural recordingopticsresolutionstatisticstechnology design

Identifiers

PMID25653613
PMCPMC4301009

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.