ArticleFrontiers in systems neuroscience2014
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
VertiGO! - Get up and GO! With the Vestibular Implant
Electrical Stimulation of the Peripheral Vestibular System in Order to Develop a Vestibular Implant
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Vestibular implant: does it really work? A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Vestibulocochlear implant (VCI) modulation improves mid and high frequency vestibulo-ocular reflex (VOR).Journal of neurology · 2026Article
- Assessing Thresholds for Nerve Activation and Action Potential Block Using a Multielectrode Array to Minimize External Stimulation.Bioengineering (Basel, Switzerland) · 2025Article
- Clinical Research on Positron Emission Tomography Imaging of the Neuro-Stimulation System in Patients with Cochleo-Vestibular Implants: Is There a Response Beyond the Peripheral Organ?Journal of clinical medicine · 2025Article
- Enhancing balance and auditory function in bilateral vestibulopathy through otolithic vestibular stimulation: insights from a pilot study on cochlea-vestibular implant efficacy.Frontiers in neurology · 2025Article
- Chronic Unilateral Vestibular Hypofunction: Insights into Etiologies, Clinical Subtypes, Diagnostics and Quality of Life.Journal of clinical medicine · 2024Article
- The vestibular implant: effects of stimulation parameters on the electrically-evoked vestibulo-ocular reflex.Frontiers in neurology · 2024Article
- Article
- Multi-frequency VEMPs improve detection of present otolith responses in bilateral vestibulopathy.Frontiers in neurology · 2024Article
- Chronic symptoms in patients with unilateral vestibular hypofunction: systematic review and meta-analysis.Frontiers in neurology · 2023Review
- Bilateral vestibulopathy: a clinical update and proposed diagnostic algorithm.Frontiers in neurology · 2023Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Vestibular function in children with cochlear implant: Impact and evaluation.Frontiers in neurology · 2022Review
- Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes.Frontiers in neuroscience · 2022Article
- Optimized Signal Analysis to Quantify the Non-Linear Behaviour of the Electrically Evoked Vestibulo-Ocular Reflex in Patients with a Vestibular Implant.Audiology & neuro-otology · 2022Article
- Bilateral vestibulopathy: beyond imbalance and oscillopsia.Journal of neurology · 2020Article
- Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.Journal of neurology · 2020Article
- Introducing the DizzyQuest: an app-based diary for vestibular disorders.Journal of neurology · 2020Article
- Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans.Journal of neural engineering · 2020Article
- Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the "natural" VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the "natural" VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the "normal" vestibular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.