ArticleFrontiers in systems neuroscience2014
Lesions of either anterior orbitofrontal cortex or ventrolateral prefrontal cortex in marmoset monkeys heighten innate fear and attenuate active coping behaviors to predator threat.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Prefrontal influences on the function of the neural circuitry underlying anxious temperament in primates.Oxford open neuroscience · 2023Article
- Article
- Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Piecing together the orbitofrontal puzzle.Behavioral neuroscience · 2021Article
- Mapping the neural circuitry of predator fear in the nonhuman primate.Brain structure & function · 2021Article
- Activation of ventrolateral orbital cortex improves mouse neuropathic pain-induced anxiodepression.JCI insight · 2020Article
- Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect.Addiction biology · 2020Article
- Damage to Orbitofrontal Areas 12 and 13, but Not Area 14, Results in Blunted Attention and Arousal to Socioemotional Stimuli in Rhesus Macaques.Frontiers in behavioral neuroscience · 2020Article
- Lesion Studies in Contemporary Neuroscience.Trends in cognitive sciences · 2019Review
- Heightened Defensive Responses Following Subtotal Lesions of Macaque Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Intrinsic Functional Boundaries of Lateral Frontal Cortex in the Common Marmoset Monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Multifaceted Role of the Ventromedial Prefrontal Cortex in Emotion, Decision Making, Social Cognition, and Psychopathology.Biological psychiatry · 2018Review
- Neuroanatomy of Anxiety: A Brief Review.Cureus · 2018Review
- Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys.Biological psychiatry · 2017Article
- Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2017Article
- A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey.Developmental neurobiology · 2017Review
- Beyond the Medial Regions of Prefrontal Cortex in the Regulation of Fear and Anxiety.Frontiers in systems neuroscience · 2016Review
- Chronic Inactivation of the Orbitofrontal Cortex Increases Anxiety-Like Behavior and Impulsive Aggression, but Decreases Depression-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ventral prefrontal cortex is an integral part of the neural circuitry that is dysregulated in mood and anxiety disorders. However, the contribution of its distinct sub-regions to the regulation of negative emotion are poorly understood. Recently we implicated both the ventrolateral prefrontal cortex (vlPFC) and anterior orbitofrontal cortex (antOFC) in the regulation of conditioned fear and anxiety responses to a social stimulus, i.e., human intruder, in the marmoset monkey. In the present study we extend our investigations to determine the role of these two regions in regulating innate responses and coping strategies to a predator stimulus, i.e., a model snake. Both the vlPFC and antOFC lesioned groups exhibited enhanced anxiety-related responses to the snake in comparison to controls. Both groups also showed a reduction in active coping behavior. These results indicate that the vlPFC and antOFC contribute independently to the regulation of both innate fear and, as previously reported, conditioned fear, and highlight the importance of these regions in producing stimulus-appropriate coping responses. The finding that dysregulation in two distinct prefrontal regions produces the apparently similar behavioral phenotype of heightened negative emotion provides insight into the varied etiology that may underlie this symptom across a wide variety of neuropsychiatric conditions with implications for personalized treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.