ArticleFrontiers in neuroscience2014
Impact of hematocrit on measurements of the intrinsic brain.
Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Using explainable machine learning to elucidate social and neurobehavioral risk factors linked to nonmedicinal opioid use in young adults.Scientific reports · 2025Article
- An information-theoretic analysis of resting-state versus task fMRI.Network neuroscience (Cambridge, Mass.) · 2023Article
- Variability in Resting-State Functional Magnetic Resonance Imaging: The Effect of Body Mass, Blood Pressure, Hematocrit, and Glycated Hemoglobin on Hemodynamic and Neuronal Parameters.Brain connectivity · 2022Article
- Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Arterial blood stealing as a mechanism of negative BOLD response: From the steady-flow with nonlinear phase separation to a windkessel-based model.Journal of theoretical biology · 2021Review
- Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies.Neuroimage. Reports · 2021Article
- Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition.NeuroImage · 2020Article
- Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.Frontiers in neuroscience · 2020Article
- Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model.The Journal of international medical research · 2018Article
- Mapping of brain tissue hematocrit in glioma and acute stroke using a dual autoradiography approach.Scientific reports · 2018Article
- Article
- Long-term acclimatization to high-altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain.Brain and behavior · 2016Article
- The impact of hematocrit on oxygenation-sensitive cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016Article
Corrections and comments
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3 authors.
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Abstract
Blood oxygenation level dependent (BOLD)-based functional MRI (fMRI) is a widely utilized neuroimaging technique for mapping brain function. Hematocrit (HCT), a global hematologic marker of the amount of hemoglobin in blood, is known to impact task-evoked BOLD activation. Yet, its impact on resting-state fMRI (R-fMRI) measures has not been characterized. We address this gap by testing for associations between HCT level and inter-individual variation in commonly employed R-fMRI indices of intrinsic brain function from 45 healthy adults. Given known sex differences in HCT, we also examined potential sex differences. Variation in baseline HCT among individuals were associated with regional differences in four of the six intrinsic brain indices examined. Portions of the default (anterior cingulate cortex/medial prefrontal cortex: ACC/MPFC), dorsal attention (intraparietal sulcus), and salience (insular and opercular cortex) network showed relationships with HCT for two measures. The relationships within MPFC, as well as visual and cerebellar networks, were modulated by sex. These results suggest that inter-individual variations in HCT can serve as a source of variations in R-fMRI derivatives at a regional level. Future work is needed to delineate whether this association is attributable to neural or non-neuronal source of variations and whether these effects are related to acute or chronic differences in HCT level.
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