ArticleJournal of multidisciplinary healthcare2015
Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression.
Article in Journal of multidisciplinary healthcare, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Perinatal depression impairs placental angiogenesis and fetal growth in mice: protective effects of betaine supplementation.Frontiers in psychiatry · 2026Article
- Betaine, a Potential Therapeutic Alternative for the Treatment of Depression.Current drug targets · 2025Review
- Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice.Molecular brain · 2024Article
- Untargeted Plasma Metabolomic Profiling in Patients with Depressive Disorders: A Preliminary Study.Metabolites · 2024Article
- The major biogenic amine metabolites in mood disorders.Frontiers in psychiatry · 2024Review
- Betaine Ameliorates Depressive-Like Behaviors in Zinc Oxide Nanoparticles Exposed Mice.Biological trace element research · 2022Article
- The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach.Nutrients · 2022Review
- Comparative Lipidomic and Metabolomic Analyses Reveal the Mystery of Lacquer Oil fromFrontiers in pharmacology · 2022Article
- Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice.Archives of Razi Institute · 2021Article
- A comparative metabolomics analysis of the halophyte Suaeda salsa and Salicornia europaea.Environmental geochemistry and health · 2021Article
- Metabolomic markers of antepartum depression and suicidal ideation.Journal of affective disorders · 2020Article
- Methionine Administration in Pregnant Rats Causes Memory Deficit in the Offspring and Alters Ultrastructure in Brain Tissue.Neurotoxicity research · 2018Article
- Effects of L-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats.Psychopharmacology · 2018Article
- Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort.Depression and anxiety · 2017Article
- Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice.Psychopharmacology · 2016Article
- Preliminary results of a randomized controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in patients with mild depression.International journal of general medicine · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundS-adenosyl-methionine (SAMe) is a common add-on treatment used to counteract depressive symptoms in subjects with mild-to-moderate depression, who are low responders to other antidepressant drugs. However, there is some concern about the possible impact of SAMe therapy on homocysteine levels. Betaine is known both to counteract high level of homocysteine in plasma and to increase liquor and plasma levels of SAMe, thus potentiating its effect.
aimTo evaluate the role played by betaine, administered along with SAMe, in potentiating the antidepressive role played by SAMe administered as such.
methodsThe study enrolled 46 subjects with a diagnosis of mild-to-moderate depression according to the Beck Depression Inventory Scale II. All the subjects had a suboptimal control of their symptoms. After randomization, they were treated with adjunctive treatment with either Samyr(®) (enteric-coated SAMe) or DDM Metile(®) (enteric-coated SAMe plus betaine) for 90 days.
resultsBoth treatments acted similarly in improving symptoms such as anxiety, psychomotor agitation, feelings of helplessness and worthlessness, physical efficiency, and somatization, but treatment with DDM Metile(®) determined better statistically significant results following a 90-day therapy. Tolerability and compliance were overlapping in both the treatments.
conclusionThe association of SAMe plus betaine seemed to demonstrate more effectiveness than SAMe alone when administered as an add-on therapy to subjects, affected by mild-to-moderate depression, who were low responders to conventional antidepressants.
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