ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Synaptic circuit organization of motor corticothalamic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed, 141 citations in OpenAlex.
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer cortical neurons after noise trauma.Science advances · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.NPJ Parkinson's disease · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Direct excitatory loop and theta resonance in the anterior cingulate-mediodorsal thalamic circuit.Communications biology · 2025Article
- A scalable, all-optical method for mapping synaptic connectivity with cell-type specificity.bioRxiv : the preprint server for biology · 2025Article
- Corticothalamic neurons in motor cortex have a permissive role in motor execution.Nature communications · 2025Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers.eLife · 2024Article
- Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics.Cell reports · 2023Article
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- A CRE/DRE dual recombinase transgenic mouse reveals synaptic zinc-mediated thalamocortical neuromodulation.Science advances · 2023Article
- Manipulation-specific cortical activity as mice handle food.Current biology : CB · 2022Article
16 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
Corticothalamic (CT) neurons in layer 6 constitute a large but enigmatic class of cortical projection neurons. How they are integrated into intracortical and thalamo-cortico-thalamic circuits is incompletely understood, especially outside of sensory cortex. Here, we investigated CT circuits in mouse forelimb motor cortex (M1) using multiple circuit-analysis methods. Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔ PT excitatory connectivity. Disynaptic inhibition systematically accompanied excitation in these pathways, scaling with the amplitude of excitation according to both presynaptic (class-specific) and postsynaptic (cell-by-cell) factors. In particular, CT neurons evoked proportionally more inhibition relative to excitation (I/E ratio) than IT neurons. Furthermore, the amplitude of inhibition was tuned to match the amount of excitation at the level of individual neurons; in the extreme, neurons receiving no excitation received no inhibition either. Extending these studies to dissect the connectivity between cortex and thalamus, we found that M1-CT neurons and thalamocortical neurons in the ventrolateral (VL) nucleus were remarkably unconnected in either direction. Instead, VL axons in the cortex excited both IT and PT neurons, and CT axons in the thalamus excited other thalamic neurons, including those in the posterior nucleus, which additionally received PT excitation. These findings, which contrast in several ways with previous observations in sensory areas, illuminate the basic circuit organization of CT neurons within M1 and between M1 and thalamus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.