ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution.Science advances · 2025Article
- C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins.Current biology : CB · 2024Article
- Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans.PLoS biology · 2023Article
- The diverse functions of the DEG/ENaC family: linking genetic and physiological insights.The Journal of physiology · 2023Article
- Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans.Genetics · 2022Article
- A C. elegans model for neurodegeneration in Cockayne syndrome.Nucleic acids research · 2020Article
- CYLD, a mechanosensitive deubiquitinase, regulates TGFβ signaling in load-induced bone formation.Bone · 2020Article
- Progressive recruitment of distal MEC-4 channels determines touch response strength inThe Journal of general physiology · 2019Article
- HowGenetics · 2019Review
- The tactile receptive fields of freely moving Caenorhabditis elegans nematodes.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Article
- Temporal processing and context dependency ineLife · 2018Article
- Distinct effects of tubulin isotype mutations on neurite growth inMolecular biology of the cell · 2017Article
- Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.Cell reports · 2017Article
- Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Molecular biology of the cell · 2016Article
- The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans.PeerJ · 2016Article
- Tissue mechanics govern the rapidly adapting and symmetrical response to touch.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference.G3 (Bethesda, Md.) · 2015Article
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2 authors.
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Abstract
In Caenorhabditis elegans, gentle touch is sensed by the anterior (ALM and AVM) and posterior (PLM) touch receptor neurons. Anterior, but not posterior, touch is affected by several stress conditions via the action of AKT kinases and the DAF-16/FOXO transcription factor. Here we show that a ubiquitination-dependent mechanism mediates such effects. AKT-1/AKT kinase and DAF-16 alter the transcription of mfb-1, which encodes an E3 ubiquitin ligase needed for the ubiquitination of the mechanosensory channel subunit MEC-4. Ubiquitination of MEC-4 reduces the amount of MEC-4 protein in the processes of ALM neurons and, consequently, the mechanoreceptor current. Even under nonstress conditions, differences in the amount of MFB-1 appear to cause the PLM neurons to be less sensitive to touch than the ALM neurons. These studies demonstrate that modulation of surface mechanoreceptors can regulate the sensitivity to mechanical signals.
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