ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- A systematic review of resting-state and task-based fmri in juvenile myoclonic epilepsy.Brain imaging and behavior · 2022Pooled it
- Motor Variability of Circular Movements Reveals Differences in Non-Dominant Hand and Foot Control in Autistic Adults.Journal of autism and developmental disorders · 2026Article
- Gait variability development in autistic individuals across childhood and adulthood.Research square · 2026Article
- Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex.Annals of the Child Neurology Society · 2026Article
- Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026Article
- The association between motor coordination impairment and altered functional connectivity among autistic children.Frontiers in pediatrics · 2026Article
- Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children.Research in autism · 2025Article
- Plumbagin Alleviates Social Behavior Deficits in a Valproic Acid Model of Autism by Reducing Glial Activation and Oxidative Stress in the Cerebellum.Neurochemical research · 2025Article
- Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood.Journal of neurodevelopmental disorders · 2025Article
- Terra Incognita - Contributions of the Olivo-Cerebellar System to Autism Spectrum Disorder.Cerebellum (London, England) · 2025Review
- Motor Control Adherence to the Two-thirds Power Law Differs in Autistic Development.Journal of autism and developmental disorders · 2025Article
- Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents.Autism research : official journal of the International Society for Autism Research · 2025Article
- Atypical Impact of Action Effect Delay on Motor Performance in Autism.Journal of autism and developmental disorders · 2025Article
- Hidden social and emotional competencies in autism spectrum disorders captured through the digital lens.Frontiers in psychiatry · 2025Article
- The effect of football (soccer) heading on gross and fine motor control in women.Frontiers in sports and active living · 2025Article
- Interceptive abilities in autism spectrum disorder: Comparing naturalistic and virtual visuomotor tasks.Autism research : official journal of the International Society for Autism Research · 2024Article
- Investigating how prior knowledge influences perception and action in developmental coordination disorder.Quarterly journal of experimental psychology (2006) · 2024Article
- Functional upper-extremity movements in autism: A narrative literature review.Research in autism spectrum disorders · 2024Article
- Enhanced motor noise in an autism subtype with poor motor skills.Molecular autism · 2024Article
- The crucial role of the cerebellum in autism spectrum disorder: Neuroimaging, neurobiological, and anatomical insights.Health science reports · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Sensorimotor abnormalities are common in autism spectrum disorder (ASD) and among the earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals with ASD also showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.