ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
A central neural pathway controlling odor tracking in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larvalFrontiers in physiology · 2023Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Article
- Octopaminergic neurons have multiple targets inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Review
- Untangling the wires: development of sparse, distributed connectivity in the mushroom body calyx.Cell and tissue research · 2021Review
- Neural Substrates of Drosophila Larval Anemotaxis.Current biology : CB · 2019Article
- Monitoring brain activity and behaviour in freely moving Drosophila larvae using bioluminescence.Scientific reports · 2018Article
- Article
- FIMTrack: An open source tracking and locomotion analysis software for small animals.PLoS computational biology · 2017Article
- A model for non-monotonic intensity coding.Royal Society open science · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Chemotaxis is important for the survival of most animals. How the brain translates sensory input into motor output beyond higher olfactory processing centers is largely unknown. We describe a group of excitatory neurons, termed Odd neurons, which are important for Drosophila larval chemotaxis. Odd neurons receive synaptic input from projection neurons in the calyx of the mushroom body and project axons to the central brain. Functional imaging shows that some of the Odd neurons respond to odor. Larvae in which Odd neurons are silenced are less efficient at odor tracking than controls and sample the odor space more frequently. Larvae in which the excitability of Odd neurons is increased are better at odor intensity discrimination and odor tracking. Thus, the Odd neurons represent a distinct pathway that regulates the sensitivity of the olfactory system to odor concentrations, demonstrating that efficient chemotaxis depends on processing of odor strength downstream of higher olfactory centers.
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