Evidence map›Paper›PMID 25653009›Full record

Trial reportBMC complementary and alternative medicine2015

Effect of Tai Chi on mononuclear cell functions in patients with non-small cell lung cancer.

Jing Liu, Peijie Chen, Ru Wang, Yonghong Yuan, Xueqiang Wang, Chunying Li

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  7. The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  8. Pooled it
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  10. Health benefits of tai chi: What is the evidence?Canadian family physician Medecin de famille canadien · 2016
    Pooled it
  11. Review
  12. Article
  13. Article
  14. Article
  15. Immunomodulatory Effects in Healthy Individuals Following a 4-Week Taoist Qigong Intervention: A Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  16. Exercise Rehabilitation and Chronic Respiratory Diseases: Effects, Mechanisms, and Therapeutic Benefits.International journal of chronic obstructive pulmonary disease · 2023
    Review
  17. Review
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing LiuDepartment of Martial Arts, Shanghai University of Sport, Shanghai, 200438, China. liujing_j3@163.com.
Peijie ChenDepartment of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. chengpjk@online.sh.cn.
Ru WangDepartment of Sports Medicine, Shanghai University of Sport, Shanghai, 200438, China. wangru0612@163.com.
Yonghong YuanDepartment of Sports Leisure, Shanghai University of Sport, Shanghai, 200438, China. yuanyonghong@hotmail.com.
Xueqiang WangDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China. xwang@hotmail.com.
Chunying LiDepartment of Biochemistry & Molecular Biology, Wayne State University School of Medicine, 540 E. Canfield, 5312 Scott, Detroit, Michigan, 48201, USA. cl@med.wayne.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTai Chi is the Chinese traditional medicine exercise for mind-body health. The objective of this study is to investigate the effect of Tai Chi Chuan (TCC) exercise on the proliferative and cytolytic/tumoricidal activities of peripheral blood mononuclear cells (PBMCs) in postsurgical non-small cell lung cancer (NSCLC) patients.

methodsPatients (n = 27) were randomly divided into the control group (n = 13) and the TCC group (n = 14). TCC group participated in Tai Chi 24-type exercise for 16 weeks, 60-min every time, and three times a week. Peripheral blood was collected and PBMCs isolated before and after the 16-week TCC, PBMC proliferation and co-culture of PBMCs with the NSCLC cell line A549 were performed for proliferation and cell cytolysis assays. Analysis of NKT cells, NK cells, and CD123+ and CD11c + dendritic cells were also performed.

results(1) After 16-week of TCC, cell proliferation increased significantly as compared with the control. (2) PBMCs from the TCC group also demonstrated enhanced cytolytic/oncolytic activity against A549 cells. (3) Significant differences were also found in NK cell percentage at t = 16 weeks, post-pre changes of NKT and DC11c between groups.

conclusionRegular Tai Chi exercise has the promise of enhancing PBMC proliferative and cytolytic activities in NSCLC patients. Our results affirm the value of a future trial with a larger scale and longer duration for cancer survivors.

trial registrationChiCTR-TRC-11001404 .

Indexed as

ExerciseMedicine, Chinese TraditionalTai JiAgedCarcinoma, Non-Small-Cell LungCell Line, TumorDendritic CellsFemaleHumansKiller Cells, NaturalLeukocytes, MononuclearMaleMiddle AgedSurvivorsTime Factors

Identifiers

PMID25653009
PMCPMC4321705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.