Evidence map›Paper›PMID 25652894›Full record

ReviewNanomedicine : nanotechnology, biology, and medicine2015

Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Surya K Mallapragada, Timothy M Brenza, JoEllyn M McMillan, Balaji Narasimhan, Donald S Sakaguchi, Anup D Sharma, Svitlana Zbarska, Howard E Gendelman

Open access · hybridAbstract readReview
In one paragraph

Review in Nanomedicine : nanotechnology, biology, and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Disentangling Mitochondria in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  7. 110Industrial & engineering chemistry research · 2019
    Article
  8. Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.Journal of biomedical materials research. Part A · 2018
    Article
  9. Article
  10. Neuropharmacologic Approaches to Restore the Brain's Microenvironment.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016
    Review
  11. Article
  12. Nano-enabled delivery of diverse payloads across complex biological barriers.Journal of controlled release : official journal of the Controlled Release Society · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Surya K MallapragadaDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA USA. Electronic address: suryakm@iastate.edu.
Timothy M BrenzaDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
JoEllyn M McMillanDepartment of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE, USA.
Balaji NarasimhanDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
Donald S SakaguchiDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA USA.
Anup D SharmaDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA USA.
Svitlana ZbarskaDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA USA.
Howard E GendelmanDepartment of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: hegendel@unmc.edu.
Iowa State University · USUniversity of Nebraska Medical Center · US

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., FOX, HOWARD S · 2000 to 2021
$37.7M
Targeted Neuro Protection of HIV-1 Associated Neurologic DiseaseP01MH064570 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 2001 to 2014
$19.4M
Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2010 to 2019
$16.8M
Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Neuroprotective Immunity and HIV DementiaR01NS034239 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Howard E Gendelman, R Lee Mosley · 1995 to 2026
$12.3M
Proteomics CoreP01NS043985 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2003 to 2012
$11.8M
Role of EAAT2 and AEG-1 in Astrocyte Dysfunction and NeurodegenerationP01NS031492 · NINDS · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI FISHER, PAUL B · 1993 to 2007
$10.9M
Nanomedicine and NeuroAIDSR01NS036126 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 1997 to 2017
$5.7M
Novel Kinase and Nanoformulated Protease Inhibitors for Eradication of CNS HIV-1R01MH104147 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 2014 to 2018
$3.2M
SMART HANDR01AG043540 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E, POLUEKTOVA, LARISA Y · 2013 to 2017
$3.1M
NeuronanomedicineR13NS083315 · NINDS · AMERICAN SOCIETY FOR NANOMEDICINE I · PI GENDELMAN, HOWARD E · 2013 to 2013
$25k
NIA NIH HHS R01 AG043540NIDA NIH HHS P01 DA028555NIGMS NIH HHS P20 GM103480NIMH NIH HHS P01 MH064570NIMH NIH HHS P01 MH64570NIMH NIH HHS P30 MH062261NIMH NIH HHS R01 MH104147NINDS NIH HHS 2R01 NS034239NINDS NIH HHS P01 NS031492NINDS NIH HHS P01 NS043985NINDS NIH HHS P01 NS43985NINDS NIH HHS R01 NS034239NINDS NIH HHS R01 NS036126NINDS NIH HHS R13 NS083315
6 · The paper itself

Abstract

Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders. From the clinical editor: Nanoneuromedicine is a branch of nanomedicine that specifically looks at the nervous system. In the clinical setting, a fundamental hurdle in nervous system disorders is due to an inherent inability of nerve cells to regenerate after damage. Nanotechnology can offer new approaches to overcome these challenges. This review describes recent developments in nanomedicine delivery systems that would affect stem cell repair and regeneration in the nervous system.

Indexed as

AgingNeural Stem CellsDrug Delivery SystemsNanomedicineNanostructuresNervous System DiseasesDrug developmentNanoformulationNanoneuromedicineNanotechnologyTargeting

Identifiers

PMID25652894
PMCPMC4628726
OpenAlexW2005510687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.