ArticleJournal of biomedical optics2015
Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.Journal of neurosurgery · 2018Trial
- Depth estimation from wavelength-dependent fluorescence spread profiles across NIR-I and NIR-II.Journal of biomedical optics · 2026Article
- Evaluation of analytical models to estimate depth of fluorescence objects in biological media.Journal of biomedical optics · 2026Article
- Deep learning-enabled fluorescence imaging for surgical guidance:Journal of biomedical optics · 2025Article
- Deep learning based depth map estimation of protoporphyrin IX in turbid media using dual wavelength excitation fluorescence.Biomedical optics express · 2023Article
- Quantitative tumor depth determination using dual wavelength excitation fluorescence.Biomedical optics express · 2022Article
- First experience with spatial frequency domain imaging and red-light excitation of protoporphyrin IX fluorescence during tumor resection.Biomedical optics express · 2020Article
- Optical Principles of Fluorescence-Guided Brain Tumor Surgery: A Practical Primer for the Neurosurgeon.Neurosurgery · 2019Review
- Visualization technologies for 5-ALA-based fluorescence-guided surgeries.Journal of neuro-oncology · 2019Review
- Toward Quantitative Neurosurgical Guidance With High-Resolution Microscopy of 5-Aminolevulinic Acid-Induced Protoporphyrin IX.Frontiers in oncology · 2019Article
- Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.Journal of biomedical optics · 2018Article
- Fluorescence depth estimation from wide-field optical imaging data for guiding brain tumor resection: a multi-inclusion phantom study.Biomedical optics express · 2017Article
- Noninvasive depth estimation using tissue optical properties and a dual-wavelength fluorescent molecular probeBiomedical optics express · 2017Article
- Multimodal fluorescence molecular imaging for in vivo characterization of skin cancer using endogenous and exogenous fluorophores.Journal of biomedical optics · 2017Article
- Brain tumor delineation enhanced by moxifloxacin-based two-photon/CARS combined microscopy.Biomedical optics express · 2017Article
- Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls.Scientific reports · 2017Article
- Depth-Resolved Multispectral Sub-Surface Imaging Using Multifunctional Upconversion Phosphors with Paramagnetic Properties.ACS applied materials & interfaces · 2015Article
- Macroscopic-imaging technique for subsurface quantification of near-infrared markers during surgery.Journal of biomedical optics · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A diffuse imaging method is presented that enables wide-field estimation of the depth of fluorescent molecular markers in turbid media by quantifying the deformation of the detected fluorescence spectra due to the wavelength-dependent light attenuation by overlying tissue. This is achieved by measuring the ratio of the fluorescence at two wavelengths in combination with normalization techniques based on diffuse reflectance measurements to evaluate tissue attenuation variations for different depths. It is demonstrated that fluorescence topography can be achieved up to a 5 mm depth using a near-infrared dye with millimeter depth accuracy in turbid media having optical properties representative of normal brain tissue. Wide-field depth estimates are made using optical technology integrated onto a commercial surgical microscope, making this approach feasible for real-world applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.