ArticleBrain structure & function2016
The neostriatum: two entities, one structure?
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Article
- The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes.Frontiers in neuroscience · 2021Article
- Functionally matched domains in parietal-frontal cortex of monkeys project to overlapping regions of the striatum.Progress in neurobiology · 2020Article
- Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability.PloS one · 2020Article
- Compartmental function and modulation of the striatum.Journal of neuroscience research · 2019Review
- Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons.Cell reports · 2019Article
- Lesions of the Patch Compartment of Dorsolateral Striatum Disrupt Stimulus-Response Learning.Neuroscience · 2019Article
- Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.The European journal of neuroscience · 2019Article
- A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell.Neuron · 2019Review
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Striosome-based map of the mouse striatum that is conformable to both cortical afferent topography and uneven distributions of dopamine D1 and D2 receptor-expressing cells.Brain structure & function · 2018Article
- Gene therapy approaches in the non-human primate model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Compensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents.Frontiers in neuroscience · 2018Review
- Article
- Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism.Frontiers in neuroanatomy · 2017Article
- Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake.Temperature (Austin, Tex.)Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The striosome (or patch) was first identified with anatomical techniques as neurons organized in a three-dimensional labyrinth inserted in and interdigitating the rest of neostriatum: the matrix. Striosome and matrix rapidly became known as two neuronal compartments expressing different biochemical markers, embryonic development and afferent and efferent connectivity. In spite of extensive intrinsic neuronal axonal and dendritic extensions supposed to exchange information between matrix and striosomes, evidence suggested the presence of independent areas. Here, we report that indeed these two areas do not exchange synaptic information. We used genetic expression of channel rhodopsin 2 carried by adeno-associated virus serotype 10 (AAVrh10) that only expresses in neurons of the matrix compartment. Whole-cell patch-clamp recordings of matrix neurons activated by light pulses consistently produced inhibitory postsynaptic currents (IPSCs), but the same manipulation did not evoke IPSCs in striosome neurons. The matrix contains both direct and indirect striatal output pathways. By targeting striatal matrix expression of designer receptors exclusively activated by a designer drug (DREADD) hM3di carried by AAVrh10, we were able to inhibit the matrix neuronal compartment of the dorsolateral striatum during performance of a learned single-pellet reach-to-grasp task. As expected, inhibition of matrix neurons by systemic administration of DREADD agonist clozapine-n-oxide interfered with performance of the learned task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.