ArticleAsian journal of andrology
Effect of transient scrotal hyperthermia on sperm parameters, seminal plasma biochemical markers, and oxidative stress in men.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 152 citations in OpenAlex.
- Impact of coenzyme Q10 as an adjuvant therapy to letrozole on spermiogram results and sex hormone levels in Iraqi men with infertility; randomized open label comparative study.F1000Research · 2023Trial
- Clinical Recommendations for the Management of Male Infertility: A Consensus from the Korean Society for Sexual Medicine and Andrology (KSSMA) Clinical Practice Guideline Committee.The world journal of men's health · 2026Review
- Do foot and mouth disease vaccines affect bovine bull fertility? A systematic review and meta-analysis.Veterinary and animal science · 2026Review
- Impact of Environmental Conditions During IVF Laboratory Handling on Sperm Quality.International journal of molecular sciences · 2026Article
- PTD-FNK Alleviated Heat Stress-Induced Apoptosis of Boar Sertoli Cells via the PI3K/AKT Pathway.Veterinary sciences · 2026Article
- The TENT5A-ATXN2 axis modulates germline and somatic cell survival during heat stress.Cell death & disease · 2026Article
- Associations of Lifestyle Factors with Cadmium and Nickel in Seminal Fluid of Potential Sperm Donors.Biological trace element research · 2026Article
- Synergistic amelioration of heat stress-induced testicular damage and impaired fertility by sesame seed oil and α-lipoic acid in male rats.Basic and clinical andrology · 2026Article
- Common Environmental Hazards and Male Infertility: Effects on Epididymal Immune Microenvironment.Toxics · 2026Review
- Heat shock proteins in male infertility: recent advances and clinical implications.Frontiers in cell and developmental biology · 2026Review
- Article
- Oral niacin mitigates heat-induced reproductive impairments in male mice.Scientific reports · 2025Article
- Evaluation of acute and chronic phases of COVID-19 on semen parameters and gonad hormones: A case-control study.International journal of reproductive biomedicine · 2025Article
- The COVID-19 pandemic and its consequences on men's reproductive health.Biophysical reviews · 2025Review
- A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species.Current issues in molecular biology · 2025Review
- Alterations in Semen Quality and Immune-Related Factors in Men with Infertility who Recovered from COVID-19.MedComm · 2025Article
- Article
- What is the role of pre-operative sperm DNA fragmentation index in microsurgical varicocelectomy success?Frontiers in surgery · 2025Article
- Do mobile phones and laptop computers really impact sperm?Arab journal of urology · 2025Review
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate whether different frequencies of heat exposure cause different degrees of damage to spermatogenesis. Two groups of volunteers (10 per group) received testicular warming in a 43°C water bath 10 times, for 30 min each time: group 1: 10 consecutive days; group 2: once every 3 days. Sperm parameters, epididymis and accessory sex gland function, semen plasma oxidative stress and serum sex hormones were tested before treatment and in the 16-week recovery period after treatment. At last, we found an obvious reversible decrease in sperm concentration (P = 0.005 for Group 1 and P= 0.008 for Group 2 when the minimums were compared with baseline levels, the same below), motility (P = 0.009 and 0.021, respectively), the hypoosmotic swelling test score (P = 0.007 and 0.008, respectively), total acrosin activity (P = 0.018 and 0.009, respectively), and an increase in the seminal plasma malondialdehyde concentration (P = 0.005 and 0.017, respectively). The decrease of sperm concentration was greater for Group 2 than for Group 1 (P = 0.031). We concluded that transient scrotal hyperthermia seriously, but reversibly, negatively affected the spermatogenesis, oxidative stress may be involved in this process. In addition, intermittent heat exposure more seriously suppresses the spermatogenesis compared to consecutive heat exposure. This may be indicative for clinical infertility etiology analysis and the design of contraceptive methods based on heat stress.
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