Evidence map›Paper›PMID 25652479›Full record

ArticleMedical physics2015

Evaluation of Matrix9 silicon photomultiplier array for small-animal PET.

Junwei Du, Jeffrey P Schmall, Yongfeng Yang, Kun Di, Emilie Roncali, Gregory S Mitchell, Steve Buckley, Carl Jackson, Simon R Cherry

Abstract readEvaluation Study
In one paragraph

Article in Medical physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. PET Detectors Based on Multi-Resolution SiPM Arrays.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. A Time-Walk Correction Method for PET Detectors Based on Leading Edge Discriminators.IEEE transactions on radiation and plasma medical sciences · 2017
    Article
  6. Article
  7. Characterization of Large-Area SiPM Array for PET Applications.IEEE transactions on nuclear science · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junwei DuDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Jeffrey P SchmallDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Yongfeng YangDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Kun DiDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Emilie RoncaliDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Gregory S MitchellDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California 95616.
Steve BuckleySensL Technologies Ltd., 6800 Airport Business Park, Cork, Ireland.
Carl JacksonSensL Technologies Ltd., 6800 Airport Business Park, Cork, Ireland.
Simon R CherryDepartment of Biomedical Engineering, University of California-Davis, One Shields Avenue, Davis, California, 95616.

Funding

Multimodal mPET &mMRI Imaging InstrumentationR01EB000993 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHERRY, SIMON R, JACOBS, RUSSELL E · 2004 to 2013
$9.2M
Development of a Small Animal PET Scanner Using Solid State PhotomultipliersR01CA134632 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHERRY, SIMON R, SHAH, KANAI · 2008 to 2012
$2.1M
NCI NIH HHS R01 CA134632NIBIB NIH HHS R01 EB000993NIBIB NIH HHS R01 EB00993
6 · The paper itself

Abstract

purposeThe MatrixSL-9-30035-OEM (Matrix9) from SensL is a large-area silicon photomultiplier (SiPM) photodetector module consisting of a 3 × 3 array of 4 × 4 element SiPM arrays (total of 144 SiPM pixels) and incorporates SensL's front-end electronics board and coincidence board. Each SiPM pixel measures 3.16 × 3.16 mm(2) and the total size of the detector head is 47.8 × 46.3 mm(2). Using 8 × 8 polished LSO/LYSO arrays (pitch 1.5 mm) the performance of this detector system (SiPM array and readout electronics) was evaluated with a view for its eventual use in small-animal positron emission tomography (PET).

methodsMeasurements of noise, signal, signal-to-noise ratio, energy resolution, flood histogram quality, timing resolution, and array trigger error were obtained at different bias voltages (28.0-32.5 V in 0.5 V intervals) and at different temperatures (5 °C-25 °C in 5 °C degree steps) to find the optimal operating conditions.

resultsThe best measured signal-to-noise ratio and flood histogram quality for 511 keV gamma photons were obtained at a bias voltage of 30.0 V and a temperature of 5 °C. The energy resolution and timing resolution under these conditions were 14.2% ± 0.1% and 4.2 ± 0.1 ns, respectively. The flood histograms show that all the crystals in the 1.5 mm pitch LSO array can be clearly identified and that smaller crystal pitches can also be resolved. Flood histogram quality was also calculated using different center of gravity based positioning algorithms. Improved and more robust results were achieved using the local 9 pixels for positioning along with an energy offset calibration. To evaluate the front-end detector readout, and multiplexing efficiency, an array trigger error metric is introduced and measured at different lower energy thresholds. Using a lower energy threshold greater than 150 keV effectively eliminates any mispositioning between SiPM arrays.

conclusionsIn summary, the Matrix9 detector system can resolve high-resolution scintillator arrays common in small-animal PET with adequate energy resolution and timing resolution over a large detector area. The modular design of the Matrix9 detector allows it to be used as a building block for simple, low channel-count, yet high performance, small animal PET or PET/MRI systems.

Indexed as

SiliconAnimalsPositron-Emission TomographySignal-To-Noise RatioTemperatureSilicon

Identifiers

PMID25652479
PMCPMC4297283

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.