ArticleInfection control and hospital epidemiology2015
Environmental transmission of Clostridium difficile: association between hospital room size and C. difficile Infection.
Article in Infection control and hospital epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pooled it
- Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis.Infection · 2022Pooled it
- Trends in Clostridioides Difficile Hospitalisations in Ireland (2009-2022).Irish journal of medical science · 2026Article
- Retrospective Study of the Epidemiology ofInfection and drug resistance · 2023Article
- Building upon current knowledge and techniques of indoor microbiology to construct the next era of theory into microorganisms, health, and the built environment.Journal of exposure science & environmental epidemiology · 2020Review
- Article
- Sporulation and Germination in Clostridial Pathogens.Microbiology spectrum · 2019Review
- Bayesian inference of transmission chains using timing of symptoms, pathogen genomes and contact data.PLoS computational biology · 2019Article
- Molecular epidemiology ofAntimicrobial resistance and infection control · 2019Article
- Relationship between hospital ward design and healthcare-associated infection rates: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the association between hospital room square footage and acquisition of nosocomial Clostridium difficile infection (CDI).
methodsA case-control study was conducted at a university hospital during the calendar year of 2011. Case patients were adult inpatients with nosocomial CDI. Control patients were hospitalized patients without CDI and were randomly selected and matched to cases in a 2:1 ratio on the basis of hospital length of stay in 3-day strata. A multivariate model was developed using conditional logistic regression to evaluate risk factors for nosocomial CDI.
resultsA total of 75 case patients and 150 control patients were included. On multivariate analyses, greater square footage of the hospital room was associated with a significantly increased risk of acquiring CDI (odds ratio for every 50 ft² increase, 3.00; 95% CI, 1.75-5.16; P<.001). Other factors associated with an increased risk of CDI were location in a single room (odds ratio, 3.43; 95% CI, 1.31-9.05; P=.01), malignant tumor (4.56; 1.82-11.4; P=.001), and receipt of cefepime (2.48; 1.06-5.82; P=.04) or immunosuppressants (6.90; 2.07-23.0; P=.002) within the previous 30 days.
conclusionsGreater room square footage increased the risk of acquisition of CDI in the hospital setting, likely owing to increased environmental contamination and/or difficulty in effective disinfection. Future studies are needed to determine feasible and effective cleaning protocols based on patient and room characteristics.
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Registered trials
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