ArticleScientific reports2015
Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.
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Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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12 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Identification of novel MYO19 variants in neonatal hypertrophic cardiomyopathy: a familial analysis revealing oligogenic contributors to disease severity.Orphanet journal of rare diseases · 2025Article
- Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.Scientific reports · 2024Article
- Identification of prognostic RNA editing profiles for clear cell renal carcinoma.Frontiers in medicine · 2024Article
- RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex.Cell death and differentiation · 2023Article
- Ensembles of human myosin-19 bound to calmodulin and regulatory light chain RLC12B drive multimicron transport.The Journal of biological chemistry · 2023Article
- Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.Journal of cell science · 2021Article
- Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas.Frontiers in pediatrics · 2020Review
- Genetic and molecular epidemiology of adult diffuse glioma.Nature reviews. Neurology · 2019Review
- Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes.Journal of Korean Neurosurgical Society · 2018Review
- Large Scale Identification of Variant Proteins in Glioma Stem Cells.ACS chemical neuroscience · 2018Article
- The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.American journal of epidemiology · 2016Article
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Authors and funding
32 authors at 19 institutions in 6 countries.
Ali JalaliDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas.
E Susan AmirianDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Matthew N Bainbridge1] Codified Genomics, LLC, Houston Texas [2] Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas.
Georgina N ArmstrongDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Yanhong LiuDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Spyros TsavachidisDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Shalini N JhangianiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas.
Sharon E PlonDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Ching C LauDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Elizabeth B Claus1] Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut [2] Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Dora Il'yasova1] Department of Epidemiology and Biostatistics, Georgia State University School of Public Health, Atlanta, Georgia [2] Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
Joellen SchildkrautCancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
Francis Ali-OsmanDepartment of Surgery, Duke University Medical Center, Durham, North Carolina.
Siegal Sadetzki1] Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer [2] Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Christoffer Johansen1] Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark [2] Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Richard S HoulstonSection of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Robert B JenkinsMayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
Daniel LachanceMayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Jonine L BernsteinDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Ryan T MerrellDepartment of Neurology, NorthShore University HealthSystem, Evanston, Illinois.
Margaret R WrenschDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Faith G DavisDepartment of Public Health Services, University of Alberta, Edmonton, Alberta, Canada.
Rose LaiDepartments of Neurology, Neurosurgery, and Preventive Medicine, The University of Southern California Keck School of Medicine, Los Angeles, California.
Sanjay SheteDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kenneth AldapeDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Christopher I AmosDepartment of Community and Family Medicine, Department of Genetics, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth; Hanover, New Hampshire.
Donna M MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas.
Beatrice S MelinDepartment of Radiation Sciences Oncology, Umeå University, Umeå, Sweden.
Melissa L BondyDepartment of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · USDuke Medical Center · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USAlberta Health Services · CABaylor Genetics · USCase Western Reserve University · USDanish Cancer Society · DKDartmouth College · USGeorgia State University · USID Genomics (United States) · USInstitute of Cancer Research · GBNeurological Surgery · USNorthShore University HealthSystem · USSheba Medical Center · ILUmeå University · SEUniversity of Southern California · USYale University · US
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MGenetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9MMOLECULAR EPIDEMIOLOGY OF GLIOMASR01CA070917 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI BONDY, MELISSA L · 1996 to 2004
$3.0MBiomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5MGenomic Approaches to Defining Inherited Basis of Childhood CancerR01CA138836 · NCI · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 2010 to 2012
$1.7MBaylor Research Education Program in NeurosurgeryR25NS070694 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SHETH, SAMEER ANIL · 2010 to 2023
$1.2MGermline Telomere Biology Defects in Pediatric and Young Adult Acute Myeloid LeukK23CA158148 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GRAMATGES, MARIA MONICA · 2012 to 2014
$507kNCI NIH HHS 5 P30CA125123NCI NIH HHS 5 R01CA138836NCI NIH HHS K23 CA158148NCI NIH HHS K23CA158148NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA125123NCI NIH HHS P30CA125123NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA070917NCI NIH HHS R01CA070917NCI NIH HHS R01 CA119215NCI NIH HHS R01CA119215NCI NIH HHS R01 CA126831NCI NIH HHS R01CA126831NCI NIH HHS R01 CA138836NCI NIH HHS R01CA52689NHGRI NIH HHS U54 HG003273NHGRI NIH HHS U54HG003273NINDS NIH HHS R25 NS070694NINDS NIH HHS R25NS070694PHS HHS P50097257
Abstract
Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (<0.1% frequency), non-synonymous variants. Our findings implicate the MYO19 and KIF18B genes and rare variants in SPAG9 and RUNDC1 as candidates worthy of further investigation. Burden testing and functional studies are planned.
Indexed as
Chromosomes, Human, Pair 17FamilyGenetic LinkageAdultBrain NeoplasmsFemaleGenetic VariationGliomaHumansMaleMiddle AgedMutationPedigreeSequence Analysis, DNAYoung Adult
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