ArticleThe Journal of comparative neurology2015
Two major network domains in the dorsal raphe nucleus.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Deciphering the Functions of Raphe-Hippocampal Serotonergic and Glutamatergic Circuits and Their Deficits in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Spatially integrated cortico-subcortical tracing data for analyses of rodent brain topographical organization.Scientific data · 2024Article
- Whole-brain mapping of monosynaptic afferent inputs to the CRH neurons in the medial prefrontal cortex of mice.Journal of anatomy · 2024Article
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- Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC).The European journal of neuroscience · 2022Review
- The mouse dorsal raphe nucleus as understood by temporal Fgf8 lineage analysis.The Journal of comparative neurology · 2021Article
- High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson's disease cohort.European journal of nuclear medicine and molecular imaging · 2020Article
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- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Spatiotemporal Role of Transforming Growth Factor Beta 2 in Developing and Mature Mouse Hindbrain Serotonergic Neurons.Frontiers in cellular neuroscience · 2019Article
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- Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons.Brain research · 2017Article
- Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats.Behavioural brain research · 2017Article
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- Ascending serotonin neuron diversity under two umbrellas.Brain structure & function · 2016Review
- Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices.Frontiers in cellular neuroscience · 2016Article
- Revisiting the role of raphe and serotonin in neuropsychiatric disorders.The Journal of general physiology · 2015Article
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Abstract
Serotonin neurons in the dorsal and median raphe nuclei (DR and MR) are clustered into heterogeneous groups that give rise to topographically organized forebrain projections. However, a compelling definition of the key subgroups of serotonin neurons within these areas has remained elusive. In order to be functionally distinct, neurons must participate in distinct networks. Therefore, we analyzed subregions of the DR and MR by their afferent input. Clustering methods and principal component analysis were applied in mouse to anterograde tract-tracing experiments available from the Allen Mouse Brain Connectivity Atlas. The results revealed a major break in the networks of the DR such that the caudal third of the DR was more similar in afferent innervation to the MR than it was to the rostral two-thirds of the DR. The rostral part of the DR is associated with networks controlling motor and motivated behavior, while the caudal DR is more closely aligned with regions that regulate rhythmic hippocampal activity. Thus, a major source of heterogeneity within the DR is inclusion of the caudal component, which may be more accurately viewed as a dorsal extension of the MR.
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