ArticleBioTechniques2015
Enhanced assessment of contractile dynamics in Drosophila hearts.
Article in BioTechniques, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Dual Effects of Nicotinamide on Aging-Related Arrhythmia: Protective at Low Dose, Proarrhythmic at Higher Doses.Journal of the American Heart Association · 2026Article
- Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila.Biogerontology · 2026Article
- Article
- A Drosophila cardiac myosin increases jump muscle stretch activation and shortening deactivation.Biophysical journal · 2025Article
- Article
- The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy.Cell reports · 2024Article
- Modeling a variant of unknown significance in the Drosophila ortholog of the human cardiogenic gene NKX2.5.Disease models & mechanisms · 2023Article
- Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm.Disease models & mechanisms · 2023Article
- Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy.Journal of cellular physiology · 2023Article
- Article
- A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5.Cellular and molecular life sciences : CMLS · 2022Article
- Piezo buffers mechanical stress via modulation of intracellular CaFrontiers in physiology · 2022Article
- CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.Nature communications · 2021Article
- Identification ofDisease models & mechanisms · 2020Article
- Article
- A role for actin flexibility in thin filament-mediated contractile regulation and myopathy.Nature communications · 2020Article
- Article
- Conservation of cardiac L-type CaJournal of molecular and cellular cardiology · 2018Article
- Modeling of Myotonic Dystrophy Cardiac Phenotypes inFrontiers in neurology · 2018Review
- Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The Drosophila heart has gained considerable traction as a model of cardiac development and physiology. Previously we described a semiautomatic optical heartbeat analysis (SOHA) method for quantifying functional parameters from the fly heart that facilitated its use as an organ system and disease model. Here we present an extensively rewritten version of the original SOHA program that takes advantage of additional information contained in high-speed videos of beating hearts. Program updates allow more precise quantification of cardiac contractions, increase the signal-to-noise ratio, and reduce the overall cost and time required to analyze recordings. This new SOHA version permits relatively rapid and highly accurate determination of subphases of contraction and relaxation. Importantly, the improved functionality enables the calculation of novel physiological data, suggesting that the fly model system may also be practical for screening drugs and alleles that modulate cardiac repolarization and force production.
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