ArticleBMC genomics2015
Genome-wide analysis of bHLH transcription factor and involvement in the infection by yellow leaf curl virus in tomato (Solanum lycopersicum).
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 127 citations in OpenAlex.
- FabHLH130-FaSPS1/FaINV positively contributes to the sugar accumulation in strawberry fruits.BMC plant biology · 2026Article
- Genome-wide identification and expression profiling of the bHLH transcription factor family under salt stress and hormonal treatments in cowpea (Vigna unguiculata).Scientific reports · 2026Article
- Transcriptome SNP analysis of tomato seedlings exposed to low‑dose gamma irradiation and cold plasma suggests antiviral responses.Scientific reports · 2026Article
- Basal Differences in the Transcriptional Profiles of Tomato Roots Associated with the Presence/Absence of the Resistance GenePlants (Basel, Switzerland) · 2026Article
- Full-Length Transcriptome Sequencing ofPlants (Basel, Switzerland) · 2025Article
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- Comparison of Tomato Yellow Leaf Curl Virus-Induced Gene Expression Pattern in Tomato and Tobacco Plants.The plant pathology journal · 2025Article
- Genome- and Transcriptome-Wide Characterization and Expression Analyses of bHLH Transcription Factor Family Reveal Their Relevance to Salt Stress Response in Tomato.Plants (Basel, Switzerland) · 2025Article
- Genome-wide identification and expression profiling of bHLH transcription factors associated with ferulic acid biosynthesis inFrontiers in plant science · 2025Article
- Comprehensive Genome-Wide Identification and Expression Profiling ofInternational journal of molecular sciences · 2024Article
- Genome-Wide Identification of the bHLH Gene Family inInternational journal of molecular sciences · 2024Article
- A comprehensive review onFrontiers in genetics · 2024Review
- Genome-wide identification ofPeerJ · 2024Article
- The Basic/Helix-Loop-Helix Transcription Factor Family Gene RcbHLH112 Is a Susceptibility Gene in Gray Mould Resistance of Rose (Rosa Chinensis).International journal of molecular sciences · 2023Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis of Barley bHLH Transcription Factors and the Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Molecular insights into the responses of barley to yellow mosaic disease through transcriptome analysis.BMC plant biology · 2023Article
- Genome-wide association analysis of resistance to frogeye leaf spot China race 7 in soybean based on high-throughput sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-wide identification, evolution and expression profiles analysis of bHLH gene family inFrontiers in genetics · 2023Article
- Identification of Transcriptional Networks Involved in De Novo Organ Formation in Tomato Hypocotyl Explants.International journal of molecular sciences · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe basic helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that can bind to specific DNA target sites. They have been well characterized in model plants such as Arabidopsis and rice and have been shown to be important regulatory components in many different biological processes. However, no systemic analysis of the bHLH transcription factor family has yet been reported in tomatoes. Tomato yellow leaf curl virus (TYLCV) threatens tomato production worldwide by causing leaf yellowing, leaf curling, plant stunting and flower abscission.
resultsA total of 152 bHLH transcription factors were identified from the entire tomato genome. Phylogenetic analysis of bHLH domain sequences from Arabidopsis and tomato facilitated classification of these genes into 26 subfamilies. The evolutionary and possible functional relationships revealed during this analysis are supported by other criteria, including the chromosomal distribution of these genes, the conservation of motifs and exon/intron structural patterns, and the predicted DNA binding activities within subfamilies. Distribution mapping results showed bHLH genes were localized on the 12 tomato chromosomes. Among the 152 bHLH genes from the tomato genome, 96 bHLH genes were detected in the TYLCV-susceptible and resistant tomato breeding line before (0 dpi) and after TYLCV (357 dpi) infection. As anticipated, gene ontology (GO) analysis indicated that most bHLH genes are related to the regulation of macromolecule metabolic processes and gene expression. Only four bHLH genes were differentially expressed between 0 and 357 dpi. Virus-induced gene silencing (VIGS) of one bHLH genes SlybHLH131 in resistant lines can lead to the cell death.
conclusionIn the present study, 152 bHLH transcription factor genes were identified. One of which bHLH genes, SlybHLH131, was found to be involved in the TYLCV infection through qRT-PCR expression analysis and VIGS validation. The isolation and identification of these bHLH transcription factors facilitated clarification of the molecular genetic basis for the genetic improvement of tomatoes and the development of functional gene resources for transgenic research. In addition, these findings may aid in uncovering an unexplored mechanism during the TYLCV infection in tomatoes.
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