ArticleParasites & vectors2015
Triaging informative cis-regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Integration of ATAC-seq and RNA-seq reveals temperature-responsive regulatory regions in Plasmodium falciparum asexual stages.Parasites & vectors · 2026Article
- Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation.BMC genomics · 2019Article
- What functional genomics has taught us about transcriptional regulation in malaria parasites.Briefings in functional genomics · 2019Review
- Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development.Cell host & microbe · 2018Article
- Genome-wide identification of novel intergenic enhancer-like elements: implications in the regulation of transcription in Plasmodium falciparum.BMC genomics · 2017Article
- Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor.Cell host & microbe · 2017Article
- Capturing in vivo RNA transcriptional dynamics from the malaria parasiteGenome research · 2017Article
- Integrated analysis of the Plasmodium species transcriptome.EBioMedicine · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOver 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the 5' flanking regions of these genes that may act as cis-acting factors in the promoter-based control of temporal expression. Triaging these lists to provide candidates most likely to play a role in regulating temporal expression is challenging, but important if we are to effectively design in vitro studies to validate this role.
methodsWe report here the application of a repeated search of variations of 5' flanking sequences from P. falciparum using the Finding Informative Regulatory Elements (FIRE) algorithm.
resultsOur approach repeatedly found a short-list of high scoring DNA motifs, for which cognate specific transcription factors were available, that appear to be typically associated with upregulation of mRNA accumulation during the first half of intraerythrocytic development.
conclusionsWe propose these cis-trans interactions may provide a combinatorial promoter-based control of gene expression to complement more global mechanisms of gene regulation that can account for temporal control during the second half of intraerythrocytic development.
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