ArticleMolecular microbiology2015
Examination of the Staphylococcus aureus nitric oxide reductase (saNOR) reveals its contribution to modulating intracellular NO levels and cellular respiration.
Article in Molecular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Structural basis of Neisseria meningitidis quinol dependent nitric oxide reductase activation by dimerization.Communications biology · 2026Article
- Defects in anaplerotic metabolism sensitizeMicrobiology spectrum · 2025Article
- Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers.ACS medicinal chemistry letters · 2024Article
- NorA, HmpX, and NorB Cooperate to Reduce NO Toxicity during Denitrification and Plant Pathogenesis inMicrobiology spectrum · 2022Article
- Inhibition ofFrontiers in cellular and infection microbiology · 2022Article
- Understanding the Role of the Antioxidant Drug Erdosteine and Its Active Metabolite onAntioxidants (Basel, Switzerland) · 2021Article
- Fatty acids can inhibit Staphylococcus aureus SaeS activity at the membrane independent of alterations in respiration.Molecular microbiology · 2021Article
- Bacterial-like nitric oxide synthase in the haloalkaliphilic archaeon Natronomonas pharaonis.MicrobiologyOpen · 2020Article
- Exogenous Fatty Acids Remodel Staphylococcus aureus Lipid Composition through Fatty Acid Kinase.Journal of bacteriology · 2020Article
- Flavohaemoglobin: the pre-eminent nitric oxide-detoxifying machine of microorganisms.F1000Research · 2020Review
- Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy.Science advances · 2019Article
- Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection.Scientific reports · 2019Article
- The Response ofJournal of bacteriology · 2019Article
- Interplay of Nitric Oxide Synthase (NOS) and SrrAB in Modulation ofInfection and immunity · 2019Article
- Genomic Alterations of Staphylococcus aureus ATCC 25923 after Prolonged Passage in the Laboratory.Microbiology resource announcements · 2018Article
- The Redox-Sensing Regulator Rex Contributes to the Virulence and Oxidative Stress Response ofFrontiers in cellular and infection microbiology · 2018Article
- Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology.Molecular microbiology · 2017Article
- Article
- Fluorescent Detection of Intracellular Nitric Oxide inBio-protocol · 2016Article
- Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens.Current opinion in microbiology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus nitrosative stress resistance is due in part to flavohemoprotein (Hmp). Although hmp is present in all sequenced S. aureus genomes, 37% of analyzed strains also contain nor, encoding a predicted quinol-type nitric oxide (NO) reductase (saNOR). DAF-FM staining of NO-challenged wild-type, nor, hmp and nor hmp mutant biofilms suggested that Hmp may have a greater contribution to intracellular NO detoxification relative to saNOR. However, saNOR still had a significant impact on intracellular NO levels and complemented NO detoxification in a nor hmp mutant. When grown as NO-challenged static (low-oxygen) cultures, hmp and nor hmp mutants both experienced a delay in growth initiation, whereas the nor mutant's ability to initiate growth was comparable with the wild-type strain. However, saNOR contributed to cell respiration in this assay once growth had resumed, as determined by membrane potential and respiratory activity assays. Expression of nor was upregulated during low-oxygen growth and dependent on SrrAB, a two-component system that regulates expression of respiration and nitrosative stress resistance genes. High-level nor promoter activity was also detectable in a cell subpopulation near the biofilm substratum. These results suggest that saNOR contributes to NO-dependent respiration during nitrosative stress, possibly conferring an advantage to nor+ strains in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.