ArticleJournal of oral microbiology2015
Pulp and plaque microbiotas of children with severe early childhood caries.
Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of two irrigating solutions on antimicrobial activity and clinical and radiographic success after endodontic treatment in primary teeth: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Effect of rubusoside, a natural sucrose substitute, on the metabolism of Scardovia wiggsiae: a novel potential cariogenic pathogen.BMC biology · 2025Article
- A deep learning feature importance test framework for integrating informative high-dimensional biomarkers to improve disease outcome prediction.Briefings in bioinformatics · 2024Article
- Bacterial dynamics in the progression of caries to apical periodontitis in primary teeth of children with severe early childhood caries.Frontiers in microbiology · 2024Article
- Portable biosensor-based oral pathogenic bacteria detection for community and family applications.Analytical and bioanalytical chemistry · 2023Review
- Influence of neo-adjuvant radiotherapy on the intestinal microbiota of rectal cancer patients.Journal of cancer research and clinical oncology · 2023Article
- Oral Microbiome, Mental Health, and Sleep Outcomes During the COVID-19 Pandemic: An Observational Study in Chinese and Korean American Immigrants.Omics : a journal of integrative biology · 2023Observational
- Analysis of bacterial communities of infected primary teeth in a Mexican population.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children.BMC oral health · 2019Article
- [Recent achievements in the microbiological etiology of dental caries].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Article
- Combined analysis of the salivary microbiome and host defence peptides predicts dental disease.Scientific reports · 2018Article
- Oral Microbiome Shifts From Caries-Free to Caries-Affected Status in 3-Year-Old Chinese Children: A Longitudinal Study.Frontiers in microbiology · 2018Article
- Article
- Advances in the microbial etiology and pathogenesis of early childhood caries.Molecular oral microbiology · 2017Review
- Insights of the dental calculi microbiome of pre-Columbian inhabitants from Puerto Rico.PeerJ · 2017Article
- Oral microflora in preschool children attending a fluoride varnish program: a cross-sectional study.BMC oral health · 2016Article
- Microbiome of Deep Dentinal Caries Lesions in Teeth with Symptomatic Irreversible Pulpitis.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveBacterial invasion into pulps of primary teeth can lead to infection and premature tooth loss in children. This pilot study aimed to explore whether the microbiota of carious exposures of dental pulps resembles that of carious dentin or that of infected root canals.
designChildren with severe early childhood caries were studied. Children were consented and extent of caries, plaque, and gingivitis measured. Bacteria were sampled from carious lesion biofilms and vital carious exposures of pulps, and processed by anaerobic culture. Isolates were characterized from partial sequences of the 16S rRNA gene and identified by comparison with taxa in the Human Oral Microbiome Database (http://www.HOMD.org). The microbiotas of carious lesions and dental pulps were compared using univariate and multivariate approaches.
resultsThe microbiota of cariously exposed pulps was similar in composition to that of carious lesion biofilms except that fewer species/taxa were identified from pulps. The major taxa identified belonged to the phyla Firmicutes (mainly streptococci) and Actinobacteria (mainly Actinomyces species). Actinomyces and Selenomonas species were associated with carious lesions whereas Veillonella species, particularly Veillonella dispar was associated with pulps. Other bacteria detected in pulps included Streptococcus mutans, Parascardovia denticolens, Bifidobacterium longum, and several Lactobacillus and Actinomyces species. By principal, component analysis pulp microbiotas grouped together, whereas those in caries biofilms were widely dispersed.
conclusionsWe conclude that the microbiota of cariously exposed vital primary pulps is composed of a subset of species associated with carious lesions. Vital primary pulps had a dominant Firmicutes and Actinobacteria microbiota which contrasts with reports of endodontic infections which can harbor a gram-negative microbiota. The microbiota of exposed primary pulps may provide insight into bacterial species at the forefront of caries invasion in dentinal lesions that can invade into the pulp and the nature of species that need suppressing for successful pulp therapy.
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