ArticleMagnetic resonance in medicine2016
In vivo (1)H MRSI of glycine in brain tumors at 3T.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas.NMR in biomedicine · 2025Article
- Plasma amino acids indicate glioblastoma with ATRX loss.Amino acids · 2021Article
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.Neuro-oncology · 2020Article
- Elevated glycine detected on in vivo magnetic resonance spectroscopy in a breast cancer patient: case report and literature review.BJR case reports · 2020Article
- High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI.NeuroImage. Clinical · 2020Article
- Clinical applications of breast cancer metabolomics using high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H MRS): systematic scoping review.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Two-Year Follow-Up Magnetic Resonance Imaging and Spectroscopy Findings and Cerebrospinal Fluid Analysis of a Dog with Sandhoff's Disease.Journal of veterinary internal medicine · 2018Article
- Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.NMR in biomedicine · 2017Article
- Application of Single Voxel 1H Magnetic Resonance Spectroscopy in Hepatic Benign and Malignant Lesions.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Distinguishing Myo-Inositol From Glycine in Brain MRS at 3T: A Pitfall Using Intermediate Echo Times.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeMR spectroscopic imaging (SI) of glycine (Gly) in the human brain is challenging due to the interference of the abundant neighboring J-coupled resonances. Our aim is to accomplish reliable imaging of Gly in healthy brain and brain tumors using an optimized MR sequence scheme at 3 tesla.
methodsTwo-dimensional (1)H SI was performed with a point-resolved spectroscopy scheme. An echo time of 160 ms was used for separation between Gly and myo-inositol signals. Data were collected from eight healthy volunteers and 14 subjects with gliomas. Spectra were analyzed with the linear combination model using numerically calculated basis spectra. Metabolite concentrations were estimated with reference to creatine in white matter (WM) regions at 6.4 molar concentrations (mM).
resultsFrom a linear regression analysis with respect to the fractional gray matter (GM) content, the Gly concentrations in pure GM and WM in healthy brains were estimated to be 1.1 and 0.3 mM, respectively. Gly was significantly elevated in tumors. The tumor-to-contralateral Gly concentration ratio was more extensive with higher grades, showing ∼ 10-fold elevation of Gly in glioblastomas.
conclusionThe Gly level is significantly different between GM and WM in healthy brains. Our data indicate that SI of Gly may provide a biomarker of brain tumor malignancy.
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