ArticleAmerican journal of physiology. Renal physiology2015
Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Kidney injury molecule 1 in the early detection of acute kidney injury-a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Sex and circadian regulation of metabolic demands in the rat kidney: A modeling analysis.PloS one · 2024Article
- Sex differences in circadian regulation of kidney function of the mouse.American journal of physiology. Renal physiology · 2022Article
- Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis.Frontiers in physiology · 2022Article
- Sex-Specific Computational Models of Kidney Function in Patients With Diabetes.Frontiers in physiology · 2022Article
- Sex differences in solute and water handling in the human kidney: Modeling and functional implications.iScience · 2021Article
- A Computational Model of Kidney Function in a Patient with Diabetes.International journal of molecular sciences · 2021Review
- Association between urine pH and risk of contrast-associated acute kidney injury among patients after emergency percutaneous coronary intervention: a V-shape relationship?Clinical and experimental nephrology · 2021Observational
- Sex differences in solute transport along the nephrons: effects of NaAmerican journal of physiology. Renal physiology · 2020Article
- iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol.BioMed research international · 2020Article
- Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis.American journal of physiology. Renal physiology · 2019Article
- Solute and water transport along an inner medullary collecting duct undergoing peristaltic contractions.American journal of physiology. Renal physiology · 2019Article
- Recent advances in sex differences in kidney function.American journal of physiology. Renal physiology · 2019Article
- Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat.Mathematical medicine and biology : a journal of the IMA · 2017Article
- Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability.American journal of physiology. Renal physiology · 2017Article
- Modeling glucose metabolism and lactate production in the kidney.Mathematical biosciences · 2017Article
- A new microscope for the kidney: mathematics.American journal of physiology. Renal physiology · 2017Article
- Modeling Glucose Metabolism in the Kidney.Bulletin of mathematical biology · 2016Article
- Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study.American journal of physiology. Renal physiology · 2016Article
- Recent advances in renal hemodynamics: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2015Review
Corrections and comments
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Authors and funding
3 authors.
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Abstract
The goal of this study was to investigate the reciprocal interactions among oxygen (O2), nitric oxide (NO), and superoxide (O2 (-)) and their effects on medullary oxygenation and urinary output. To accomplish that goal, we developed a detailed mathematical model of solute transport in the renal medulla of the rat kidney. The model represents the radial organization of the renal tubules and vessels, which centers around the vascular bundles in the outer medulla and around clusters of collecting ducts in the inner medulla. Model simulations yield significant radial gradients in interstitial fluid oxygen tension (Po2) and NO and O2 (-) concentration in the OM and upper IM. In the deep inner medulla, interstitial fluid concentrations become much more homogeneous, as the radial organization of tubules and vessels is not distinguishable. The model further predicts that due to the nonlinear interactions among O2, NO, and O2 (-), the effects of NO and O2 (-) on sodium transport, osmolality, and medullary oxygenation cannot be gleaned by considering each solute's effect in isolation. An additional simulation suggests that a sufficiently large reduction in tubular transport efficiency may be the key contributing factor, more so than oxidative stress alone, to hypertension-induced medullary hypoxia. Moreover, model predictions suggest that urine Po2 could serve as a biomarker for medullary hypoxia and a predictor of the risk for hospital-acquired acute kidney injury.
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