ArticleAngewandte Chemie (International ed. in English)2015
Clotting activity of polyphosphate-functionalized silica nanoparticles.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 82 citations in OpenAlex.
- Synthesis of monodisperse inorganic polyphosphate polyPChemical science · 2025Article
- Dragon's Blood-Loaded Mesoporous Silica Nanoparticles for Rapid Hemostasis and Antibacterial Activity.Molecules (Basel, Switzerland) · 2024Article
- Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis.Bioactive materials · 2023Review
- An Adhesive/Anti-Adhesive Janus Tissue Patch for Efficient Closure of Bleeding Tissue with Inhibited Postoperative Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Porcine liver injury model to assess tantalum-containing bioactive glass powders for hemostasis.Journal of materials science. Materials in medicine · 2022Article
- Polyphosphate nanoparticles enhance the fibrin stabilization by histones more efficiently than linear polyphosphates.PloS one · 2022Article
- Advanced applications of nanotechnology in veterinary medicine.Environmental science and pollution research international · 2020Review
- Silica nanomaterials induce organ injuries by CaParticle and fibre toxicology · 2020Article
- Application of some nanoparticles in the field of veterinary medicine.International journal of veterinary science and medicine · 2019Review
- Polyphosphate in thrombosis, hemostasis, and inflammation.Research and practice in thrombosis and haemostasis · 2019Review
- Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters.ACS central science · 2018Article
- Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma.Bioconjugate chemistry · 2018Article
- Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.Advanced materials (Deerfield Beach, Fla.) · 2018Review
- Bio-inspired nanomedicine strategies for artificial blood components.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma.Scientific reports · 2017Article
- 2013 scientific sessions Sol Sherry distinguished lecture in thrombosis: polyphosphate: a novel modulator of hemostasis and thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Polyphosphate, platelets, and coagulation.International journal of laboratory hematology · 2015Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.