ArticleObesity (Silver Spring, Md.)2015
Adults with long-duration type 2 diabetes have blunted glycemic and β-cell function improvements after bariatric surgery.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03854981 (Role of Pre-operative Exercise and Nutrition Therapy on Insulin Resistance and Vascular Health in Patients Undergoing Bariatric Surgery), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Pre-operative Exercise and Nutrition Therapy on Insulin Resistance and Vascular Health in Patients Undergoing Bariatric Surgery
Who cites it
20 citing papers in PubMed.
- Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults.Scientific reports · 2021Trial
- Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes.The New England journal of medicine · 2020Trial
- Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.Cell metabolism · 2016 · on this mapTrial
- Non-invasive islet β-cell markers track with weight-loss interventions for type 2 diabetes: a prospective cohort study.International journal of obesity (2005) · 2026Article
- Prehabilitation of overweight and obese patients with dysglycemia awaiting bariatric surgery: Predicting the success of obesity treatment.World journal of diabetes · 2022Review
- Nomogram for Predicting 5-Year Diabetes Remission After Roux-en-Y Gastric Bypass Surgery in Chinese Patients with Obesity.Obesity surgery · 2022Article
- Metabolic outcomes of surgery in youth with type 2 diabetes.Seminars in pediatric surgery · 2020Review
- Bariatric Surgery in Children: Indications, Types, and Outcomes.Current gastroenterology reports · 2019Review
- Bariatric Surgery Resistance: Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness.Obesity surgery · 2017Review
- Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity.Obesity science & practice · 2017Article
- Type 2 diabetes remission following gastric bypass: does diarem stand the test of time?Surgical endoscopy · 2017Article
- Bariatric surgery and type 2 diabetes: are there weight loss-independent therapeutic effects of upper gastrointestinal bypass?Journal of internal medicine · 2016Review
- Mid-Term Remission of Type 2 Diabetes Mellitus After Laparoscopic Roux En-Y Gastric Bypass.World journal of surgery · 2016Article
- Mechanisms of improved glucose handling after metabolic surgery: the big 6.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2016Review
- Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth.Diabetes care · 2016Review
- Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass.Obesity surgery · 2016Article
- Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism.Reviews in endocrine & metabolic disorders · 2016Review
- From bariatric to metabolic surgery: Looking for a "disease modifier" surgery for type 2 diabetes.World journal of diabetes · 2016Review
- Clinical Management of Type 2 Diabetes Mellitus after Bariatric Surgery.Current atherosclerosis reports · 2015Review
- Surgical Treatment of Diabetes: Making a Case for a Pragmatic Approach.The Journal of clinical endocrinology and metabolism · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveThis study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery.
methodsTwenty-seven adults with short- (<5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined.
resultsAdults with short-duration type 2 diabetes had better HbA(1c), greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA(1c) and DI but not weight loss.
conclusionsEnhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for <5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes.
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