ArticleCell metabolism2015
Suppression of insulin production and secretion by a decretin hormone.
Article in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 147 citations in OpenAlex.
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- The gut takes it all: Enteroendocrine control of developmental growth.PLoS biology · 2026Article
- Ghrelin and relamorelin counteract hypoglycemia in mice engrafted with congenital hyperinsulinism stem cell-derived islets.Stem cells translational medicine · 2026Article
- Sexual identity of Akh neurons shapes Nucb1-dependent metabolic and reproductive plasticity.iScience · 2026Article
- The neuropeptide neuromedin U receptor NMUR-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival.PLoS genetics · 2026Article
- Single-cell transcriptomics of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Conserved Molecular Responses to Arsenite Exposure inbioRxiv : the preprint server for biology · 2026Article
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Haplotypes, Genotypes, and DNA Methylation Levels of Neuromedin U Gene Are Associated with Cardio-Metabolic Parameters: Results from the Moli-sani Study.Biomedicines · 2025Article
- Duodenal neuroendocrine cells and neuromedin U in subjects with obesity: Relationship with type 2 diabetes and glucose homeostasis.Physiological reports · 2025Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
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- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
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- UsingCells · 2023Review
- Insulin signaling in development.Development (Cambridge, England) · 2023Article
- Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.Scientific reports · 2023Article
- Ion transport peptide regulates energy intake, expenditure, and metabolic homeostasis in Drosophila.Genetics · 2022Article
- Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.Diabetologia · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Decretins, hormones induced by fasting that suppress insulin production and secretion, have been postulated from classical human metabolic studies. From genetic screens, we identified Drosophila Limostatin (Lst), a peptide hormone that suppresses insulin secretion. Lst is induced by nutrient restriction in gut-associated endocrine cells. limostatin deficiency led to hyperinsulinemia, hypoglycemia, and excess adiposity. A conserved 15-residue polypeptide encoded by limostatin suppressed secretion by insulin-producing cells. Targeted knockdown of CG9918, a Drosophila ortholog of Neuromedin U receptors (NMURs), in insulin-producing cells phenocopied limostatin deficiency and attenuated insulin suppression by purified Lst, suggesting CG9918 encodes an Lst receptor. NMUR1 is expressed in islet β cells, and purified NMU suppresses insulin secretion from human islets. A human mutant NMU variant that co-segregates with familial early-onset obesity and hyperinsulinemia fails to suppress insulin secretion. We propose Lst as an index member of an ancient hormone class called decretins, which suppress insulin output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.