ArticleBiophysical journal2015
Karyotyping human chromosomes by optical and X-ray ptychography methods.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Fast full-color pathological imaging via an optimized illumination pattern with color transfer in Fourier ptychographic microscopy (OIP-CTFPM).Biomedical optics express · 2026Article
- X-ray Ptychography Imaging of Human Chromosomes After Low-dose Irradiation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Article
- Combining Multicolor FISH with Fluorescence Lifetime Imaging for Chromosomal Identification and Chromosomal Sub Structure Investigation.Frontiers in molecular biosciences · 2021Article
- Article
- Nuclear incorporation of iron during the eukaryotic cell cycle.Journal of synchrotron radiation · 2016Article
- A review of metaphase chromosome image selection techniques for automatic karyotype generation.Medical & biological engineering & computing · 2016Review
- Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution.Scientific reports · 2016Article
- Tomography of a Cryo-immobilized Yeast Cell Using Ptychographic Coherent X-Ray Diffractive Imaging.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Sorting and identifying chromosomes, a process known as karyotyping, is widely used to detect changes in chromosome shapes and gene positions. In a karyotype the chromosomes are identified by their size and therefore this process can be performed by measuring macroscopic structural variables. Chromosomes contain a specific number of basepairs that linearly correlate with their size; therefore, it is possible to perform a karyotype on chromosomes using their mass as an identifying factor. Here, we obtain the first images, to our knowledge, of chromosomes using the novel imaging method of ptychography. We can use the images to measure the mass of chromosomes and perform a partial karyotype from the results. We also obtain high spatial resolution using this technique with synchrotron source x-rays.
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Registered trials
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