ArticleBiophysical journal2015
Particle transport through hydrogels is charge asymmetric.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Colloidal Heterostructures Enable Interfacial Transport of Immiscible Molecules in Printable Organohydrogels.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems.Molecular pharmaceutics · 2025Article
- Impact of Collagen on the Rheological and Transport Properties of Agarose Hydrogels.Gels (Basel, Switzerland) · 2025Article
- Nanoliposomes Permeability in a Microfluidic Drug Delivery Platform across a 3D Hydrogel.Pharmaceutics · 2024Article
- Nonspecific membrane-matrix interactions influence diffusivity of lipid vesicles in hydrogels.Biophysical journal · 2024Article
- Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior.Biosensors · 2023Review
- Electro-optical Study of the Anomalous Rotational Diffusion in Polymer Solutions.Macromolecules · 2023Article
- Molecular Dynamics Simulations of Rhodamine B Zwitterion Diffusion in Polyelectrolyte Solutions.The journal of physical chemistry. B · 2022Article
- Modeling spatiotemporally varying protein-protein interactions in CyLaKS, the Cytoskeleton Lattice-based Kinetic Simulator.The European physical journal. E, Soft matter · 2021Article
- Magnetic poly(acrylic acid)-based hydrogels for rapid ammonium sorption and efficient sorbent separation from sewage.Environmental science and ecotechnology · 2021Article
- Particle Diffusivity and Free-Energy Profiles in Hydrogels from Time-Resolved Penetration Data.Biophysical journal · 2021Article
- Studies of nanoparticle delivery withBioactive materials · 2020Review
- A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks.Polymers · 2020Article
- Anomalous Diffusion Inside Soft Colloidal Suspensions Investigated by Variable Length Scale Fluorescence Correlation Spectroscopy.ACS omega · 2020Article
- Protein diffusion from microwells with contrasting hydrogel domains.APL bioengineering · 2019Article
- Mucus-penetrating phage-displayed peptides for improved transport across a mucus-like model.International journal of pharmaceutics · 2018Article
- Particle Trapping Mechanisms Are Different in Spatially Ordered and Disordered Interacting Gels.Biophysical journal · 2018Article
- Designing hydrogels for controlled drug delivery.Nature reviews. Materials · 2016Article
- Quantifying the Influence of the Crowded Cytoplasm on Small Molecule Diffusion.The journal of physical chemistry. B · 2016Article
- Nanoparticle filtering in charged hydrogels: Effects of particle size, charge asymmetry and salt concentration.The European physical journal. E, Soft matter · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transport processes within biological polymer networks, including mucus and the extracellular matrix, play an important role in the human body, where they serve as a filter for the exchange of molecules and nanoparticles. Such polymer networks are complex and heterogeneous hydrogel environments that regulate diffusive processes through finely tuned particle-network interactions. In this work, we present experimental and theoretical studies to examine the role of electrostatics on the basic mechanisms governing the diffusion of charged probe molecules inside model polymer networks. Translational diffusion coefficients are determined by fluorescence correlation spectroscopy measurements for probe molecules in uncharged as well as cationic and anionic polymer solutions. We show that particle transport in the charged hydrogels is highly asymmetric, with diffusion slowed down much more by electrostatic attraction than by repulsion, and that the filtering capability of the gel is sensitive to the solution ionic strength. Brownian dynamics simulations of a simple model are used to examine key parameters, including interaction strength and interaction range within the model networks. Simulations, which are in quantitative agreement with our experiments, reveal the charge asymmetry to be due to the sticking of particles at the vertices of the oppositely charged polymer networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.