ArticleBiophysical journal2015
Three-dimensional structure of the intercalated disc reveals plicate domain and gap junction remodeling in heart failure.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging.Cardiovascular diabetology · 2025Article
- Ultrastructure and cardiac impulse propagation: scaling up from microscopic to macroscopic conduction.The Journal of physiology · 2025Review
- Mitochondrial Structure and Function in Human Heart Failure.Circulation research · 2024Review
- Realistic numerical simulations of diffusion tensor cardiovascular magnetic resonance: The effects of perfusion and membrane permeability.Magnetic resonance in medicine · 2023Article
- Article
- Electron microscopy of cardiac 3D nanodynamics: form, function, future.Nature reviews. Cardiology · 2022Review
- Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.Scientific reports · 2022Article
- Three-dimensional visualization of heart-wide myocardial architecture and vascular network simultaneously at single-cell resolution.Frontiers in cardiovascular medicine · 2022Article
- Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.Oncoimmunology · 2022Article
- Localization of NaThe Journal of physiology · 2021Article
- Intercalated disk nanoscale structure regulates cardiac conduction.The Journal of general physiology · 2021Article
- Quantification of Myocyte Disarray in Human Cardiac Tissue.Frontiers in physiology · 2021Article
- Article
- Radixin Relocalization and NonmuscleDisease markers · 2020Article
- Automated segmentation of cardiomyocyte Z-disks from high-throughput scanning electron microscopy data.BMC medical informatics and decision making · 2019Article
- Cardiomyocyte damage control in heart failure and the role of the sarcolemma.Journal of muscle research and cell motility · 2019Article
- DREADD technology reveals major impact of Gq signalling on cardiac electrophysiology.Cardiovascular research · 2019Article
- Riding the waves of the intercalated disc of the heart.Biophysical reviews · 2018Review
- Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy.Histochemistry and cell biology · 2018Article
- Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes.Journal of the American Heart Association · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
The intercalated disc (ICD) orchestrates electrochemical and mechanical communication between neighboring cardiac myocytes, properties that are perturbed in heart failure (HF). Although structural data from transmission electron microscopy two-dimensional images have provided valuable insights into the domains forming the ICD, there are currently no three-dimensional (3D) reconstructions for an entire ICD in healthy or diseased hearts. Here, we aimed to understand the link between changes in protein expression in an ovine tachypacing-induced HF model and ultrastructural remodeling of the ICD by determining the 3D intercalated disc architecture using serial block face scanning electron microscopy. In the failing myocardium there is no change to the number of ICDs within the left ventricle, but there is an almost doubling of the number of discs with a surface area of <1.0 × 10(8)μm(2) in comparison to control. The 3D reconstructions further revealed that there is remodeling of the plicate domains and gap junctions with vacuole formation around and between the contributing membranes that form the ICDs in HF. Biochemical analysis revealed upregulation of proteins involved in stabilizing the adhesive and mechanical properties consistent with the morphological changes. Our studies here have shown that in tachypacing-induced HF mechanical stresses are associated with both structural and molecular alterations. To our knowledge, these data together provide novel, to our knowledge, insights as to how remodeling at the molecular and structural levels leads to impaired intercellular communication.
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