ArticleJournal of medicinal chemistry2015
Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.
Article in Journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Pharmacokinetics and Efficacy of a Cyanide-Neutralizing [MoJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- A pilot study in the swine model of lethal cyanide intoxication indicates efficacy of a platinum-methionine complex countermeasure.Scientific reports · 2026Article
- Cobinamide, a Vitamin BToxics · 2026Article
- Detoxification of hydrogen sulfide by synthetic heme model compounds.Scientific reports · 2024Article
- The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome.JACC. Basic to translational science · 2024Article
- A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures.Chemical research in toxicology · 2022Article
- Article
- Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice.PNAS nexus · 2022Article
- Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits.Clinical toxicology (Philadelphia, Pa.) · 2022Article
- Development of sodium tetrathionate as a cyanide and methanethiol antidote.Clinical toxicology (Philadelphia, Pa.) · 2022Article
- Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.Journal of medicinal chemistry · 2021Article
- Intramuscular cobinamide as an antidote to methyl mercaptan poisoning.Inhalation toxicology · 2021Article
- Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin BNature communications · 2019Article
- Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine.Clinical toxicology (Philadelphia, Pa.) · 2019Article
- Rationally Designed Circularly Arranged Sextuple Molecule with Dimethoxyphenolic Tentacles for Ample Hunting of Cyanide.ACS omega · 2018Article
- Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.PloS one · 2018Article
- Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.Annals of the New York Academy of Sciences · 2017Article
- Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection.Annals of emergency medicine · 2017Article
- An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.Annals of the American Thoracic Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Currently available cyanide antidotes must be given by intravenous injection over 5-10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an industrial accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.