ArticleOncotarget2015
Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles - A randomized controlled double-blind crossover study among mild asthmatic subjects.Particle and fibre toxicology · 2023Trial
- Inhalation of hydrogenated vegetable oil combustion exhaust and genotoxicity responses in humans.Archives of toxicology · 2021Trial
- No oxidative stress or DNA damage in peripheral blood mononuclear cells after exposure to particles from urban street air in overweight elderly.Mutagenesis · 2015Trial
- Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis.Archives of toxicology · 2026Review
- Article
- Chronological Age and DNA Damage Accumulation in Blood Mononuclear Cells: A Linear Association in Healthy Humans after 50 Years of Age.International journal of molecular sciences · 2023Article
- The relationship of double-stranded DNA breaks in blood lymphocytes and obesity without carbohydrate metabolism disorder.Molecular and cellular biochemistry · 2022Article
- Association between Food Intake, Clinical and Metabolic Markers and DNA Damage in Older Subjects.Antioxidants (Basel, Switzerland) · 2021Article
- TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.Molecular biology reports · 2020Article
- From phenoloxidase to fecundity: food availability does not influence the costs of oxidative challenge in a wing-dimorphic cricket.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women.Biomedical reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with oxidative stress-generated damage to DNA and this could be related to metabolic disturbances. This study investigated the association between levels of oxidatively damaged DNA in peripheral blood mononuclear cells (PBMCs) and metabolic risk factors in 1,019 subjects, aged 18-93 years. DNA damage was analyzed as strand breaks by the comet assay and levels of formamidopyrimidine (FPG-) and human 8-oxoguanine DNA glycosylase 1 (hOGG1)-sensitive sites There was an association between age and levels of FPG-sensitive sites for women, but not for men. The same tendency was observed for the level of hOGG1-sensitive sites, whereas there was no association with the level of strand breaks. The effect of age on oxidatively damaged DNA in women disappeared in multivariate models, which showed robust positive associations between DNA damage and plasma levels of triglycerides, cholesterol and glycosylated hemoglobin (HbA1c). In the group of men, there were significant positive associations between alcohol intake, HbA1c and FPG-sensitive sites in multivariate analysis. The levels of metabolic risk factors were positively associated with age, yet only few subjects fulfilled all metabolic syndrome criteria. In summary, positive associations between age and levels of oxidatively damaged DNA appeared mediated by age-related increases in metabolic risk factors.
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Registered trials
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