ArticleOncotarget2015
Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Inflammation-Driven Genomic Instability: A Pathway to Cancer Development and Therapy Resistance.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Esophageal Squamous Cancer from 4NQO-Induced Mice Model: CNV Alterations.International journal of molecular sciences · 2022Article
- Potential Chemotherapeutic Effect of Selenium for Improved Canceration of Esophageal Cancer.International journal of molecular sciences · 2022Article
- Managing Cancer Drug Resistance from the Perspective of Inflammation.Journal of oncology · 2022Review
- One stomach, two subtypes of carcinoma-the differences between distal and proximal gastric cancer.Gastroenterology report · 2021Review
- Inflammation-induced DNA damage, mutations and cancer.DNA repair · 2019Review
- Validation of a Dietary Inflammatory Index (DII) and Association with Risk of Gastric Cancer: a Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Melatonin as an anti-inflammatory agent in radiotherapy.Inflammopharmacology · 2017Review
- Mesenchymal Stem Cells in Restoration of Fertility at Experimental Pelvic Inflammatory Disease.Stem cells international · 2017Article
- Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis.Oncotarget · 2016Article
- DNA Damage: From Chronic Inflammation to Age-Related Deterioration.Frontiers in genetics · 2016Review
- Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone.PloS one · 2016Article
- Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cardia cancer (GCC) is a highly aggressive disease associated with chronic inflammation. To investigate the relationship between DNA damage response (DDR) and chronic inflammation, we collected 100 non-tumor gastric cardia specimens of Chaoshan littoral, a high-risk region for esophageal and gastric cardia cancer. A significantly higher proportion of severe chronic inflammation was found in dysplastic epithelia (80.9%) in comparison with that in non-dysplastic tissues (40.7%) (P<0.001). Immunohistochemical analysis demonstrated that DNA damage response was parallel with the chronic inflammation degrees from normal to severe inflammation (P<0.05). We found that DNA damage response was progressively increased with the progression of precancerous lesions (P<0.05). These findings provide pathological evidence that persistent chronic inflammation-related DNA damage response may be a driving force of gastric cardia carcinogenesis. Based on these findings, DNA damage response in non-malignant tissues may become a promising biomedical marker for predicting malignant transformation in the gastric cardia.
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Registered trials
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