ArticleJournal of the American Chemical Society2015
X-ray radiation induces deprotonation of the bilin chromophore in crystalline D. radiodurans phytochrome.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes.Science advances · 2025Article
- Conserved histidine and tyrosine determine spectral responses through the water network in Deinococcus radiodurans phytochrome.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Relevance of the Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming inAstrobiology · 2021Article
- Structural elements regulating the photochromicity in a cyanobacteriochrome.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Photoreversible interconversion of a phytochrome photosensory module in the crystalline state.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Choosing the optimal spectroscopic toolkit to understand protein function.Bioscience reports · 2017Article
- Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers.Nature methods · 2017Article
- The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography.Scientific reports · 2016Article
- Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography.Structure (London, England : 1993) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We report that in the red light-absorbing (Pr) state, the bilin chromophore of the Deinococcus radiodurans proteobacterial phytochrome (DrBphP) is hypersensitive to X-ray photons used in typical synchrotron X-ray protein crystallography experiments. This causes the otherwise fully protonated chromophore to deprotonate without additional major structural changes. These results have major implications for our understanding of the structural and chemical characteristics of the resting and intermediate states of phytochromes and other photoreceptor proteins.
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Registered trials
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